9OUK

DDB1-CRBN with Ikaros(ZF2) and DEG-47: composite map and model submission

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA damage-binding protein 1	polymer	844	94389.2	1	UniProt (Q16531)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
2	B (B)	Protein cereblon	polymer	449	51563.8	1	UniProt (Q96SW2)	Homo sapiens (human)
3	C (C)	DNA-binding protein Ikaros	polymer	57	6539.5	1	UniProt (Q13422)	Homo sapiens (human)	Ikaros family zinc finger protein 1,Lymphoid transcription factor LyF-1
4	D, F (B, C)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	E (B)	N-{2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}benzamide	non-polymer		363.4	1	Chemie (A1CEK)

Sequence modifications

A: 1 - 699 (UniProt: Q16531)
A: 706 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Gly 700	-	linker
Asn 701	-	linker
Gly 702	-	linker
Asn 703	-	linker
Ser 704	-	linker
Gly 705	-	linker
Trp 1141	-	expression tag
Ser 1142	-	expression tag
His 1143	-	expression tag
Pro 1144	-	expression tag
Gln 1145	-	expression tag
Phe 1146	-	expression tag
Glu 1147	-	expression tag
Lys 1148	-	expression tag

B: 1 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	152492.5
Non-Polymers*	Number of molecules	3
	Total formula weight	494.2
All*	Total formula weight	152986.7

*Water molecules are not included.