9OQQ

Human pannexin 1 channel W74A mutant with 10mM ATP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Pannexin-1,RNA-directed RNA polymerase L chimera	polymer	691	77886.4	7	UniProt (Q96RD7) UniProt (A0A5P9VSM8) Pfam (PF00876) Pfam (PF01353)	Homo sapiens (human)	PANX1,Large structural protein,Replicase,Transcriptase
2	H, I, J, K, L... (A, B, C, D, E...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)

Sequence modifications

A, B, C, D, E, F, G: 1 - 426 (UniProt: Q96RD7)

PDB	External Database	Details
Ala 74	Trp 74	engineered mutation
Phe 427	-	linker
Glu 428	-	linker
Ser 429	-	linker
Arg 430	-	linker
Leu 431	-	linker
Val 432	-	linker
Pro 433	-	linker
Arg 434	-	linker
Gly 435	-	linker
Ser 436	-	linker
Ala 437	-	linker

A, B, C, D, E, F, G: 438 - 678 (UniProt: A0A5P9VSM8)

PDB	External Database	Details
Ser 679	-	expression tag
Gly 680	-	expression tag
Leu 681	-	expression tag
Arg 682	-	expression tag
Ser 683	-	expression tag
His 684	-	expression tag
His 685	-	expression tag
His 686	-	expression tag
His 687	-	expression tag
His 688	-	expression tag
His 689	-	expression tag
His 690	-	expression tag
His 691	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	545204.8
Non-Polymers*	Number of molecules	7
	Total formula weight	1548.5
All*	Total formula weight	546753.3

*Water molecules are not included.