9OPK
Crystal structure of IRAK4 with compound 1, an analog of KT-474 TBM
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Interleukin-1 receptor-associated kinase 4 | polymer | 304 | 34227.5 | 4 | UniProt (Q9NWZ3) | Homo sapiens (human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | E, H, M, S (A, B, C, D) | (8R)-N-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]-5-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 376.4 | 4 | Chemie (A1CDD) | |||
| 3 | F, G, J, K, L... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 4 | I, T (B, D) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | AA, X, Y, Z (D, A, B, C) | water | water | 18.0 | 481 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 160 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Ser 157 | - | expression tag |
| Ile 158 | - | expression tag |
| Ala 159 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 136910.0 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2496.5 | |
| All* | Total formula weight | 139406.5 |
