9OPJ

cryoEM structure of IRAK4:KT-474:CRBN-DDB1 ternary complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA damage-binding protein 1	polymer	1148	128139.6	1	UniProt (Q16531)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
2	B (B)	Protein cereblon	polymer	405	46465.4	1	UniProt (Q96SW2)	Homo sapiens (human)
3	C (Z)	Interleukin-1 receptor-associated kinase 4	polymer	461	51676.6	1	UniProt (Q9NWZ3)	Homo sapiens (human)	IRAK-4,Renal carcinoma antigen NY-REN-64
4	D (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	E (B)	(8R)-N-{3-(difluoromethyl)-1-[(1S,4R)-4-({4-[(3-{1-[(3S)-2,6-dioxopiperidin-3-yl]-3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzimidazol-4-yl}prop-2-yn-1-yl)oxy]piperidin-1-yl}methyl)cyclohexyl]-1H-pyrazol-4-yl}-5-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	non-polymer		865.9	1	Chemie (A1CDC)

Sequence modifications

A: 1 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Trp 1141	-	expression tag
Ser 1142	-	expression tag
His 1143	-	expression tag
Pro 1144	-	expression tag
Gln 1145	-	expression tag
Phe 1146	-	expression tag
Glu 1147	-	expression tag
Lys 1148	-	expression tag

B: 40 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Gly 38	-	expression tag
Ser 39	-	expression tag

Z: 1 - 460 (UniProt: Q9NWZ3)

PDB	External Database	Details
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	226281.6
Non-Polymers*	Number of molecules	2
	Total formula weight	931.3
All*	Total formula weight	227212.9

*Water molecules are not included.