9ONI
Crystal structure of dihydrofolate reductase (DHFR) from the filarial nematode W. bancrofti in complex with NADPH and methotrexate (MTX)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | dihydrofolate reductase | polymer | 192 | 22082.4 | 1 | UniProt (A0AAF5PZP7) Pfam (PF00186) UniProt (by SIFTS) (A0A4E9FIQ4) | Wuchereria bancrofti | |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | C (A) | METHOTREXATE | non-polymer | 454.4 | 1 | Chemie (MTX) | |||
| 4 | D (A) | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A: 2 - 182 (UniProt: A0AAF5PZP7)
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | expression tag |
| Ala -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22082.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1197.8 | |
| All* | Total formula weight | 23280.3 |
