9OLB

Identification of ligands for E3 ligases using fragment-based methods

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	TNF receptor-associated factor 4	polymer	194	22113.9	3	UniProt (Q9BUZ4)	Homo sapiens (human)	Cysteine-rich domain associated with RING and Traf domains protein 1,Metastatic lymph node gene 62 protein,MLN 62,RING finger protein 83
2	D (D)	Epidermal growth factor receptor	polymer	10	1134.3	1	UniProt (P00533)	Homo sapiens	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
3	E, F, G (A, B, C)	water	water		18.0	56	Chemie (HOH)

Sequence modifications

A, B, C: 292 - 466 (UniProt: Q9BUZ4)

PDB	External Database	Details
Met 291	-	initiating methionine
Leu 467	-	expression tag
Glu 468	-	expression tag
Gly 469	-	expression tag
Leu 470	-	expression tag
Val 471	-	expression tag
Pro 472	-	expression tag
Arg 473	-	expression tag
Gly 474	-	expression tag
Ser 475	-	expression tag
Gly 476	-	expression tag
Ser 477	-	expression tag
Ser 478	-	expression tag
His 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag
His 482	-	expression tag
His 483	-	expression tag
His 484	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	67476.0
All*	Total formula weight	67476.0

*Water molecules are not included.