9OL4
Cryo-EM Structure of Ryanodine Receptor 1: Drug Bound Open Conformation
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, G, M, S) | Ryanodine receptor 1 | polymer | 5037 | 565908.6 | 4 | UniProt (P11716) | Oryctolagus cuniculus (rabbit) | RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor |
| 2 | B, D, F, H (B, H, N, T) | Peptidyl-prolyl cis-trans isomerase FKBP1B | polymer | 111 | 12070.8 | 4 | UniProt (P68106) | Homo sapiens (human) | PPIase FKBP1B,12.6 kDa FK506-binding protein,12.6 kDa FKBP,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12 |
| 3 | AA, I, O, U (S, A, G, M) | CAFFEINE | non-polymer | 194.2 | 4 | Chemie (CFF) | |||
| 4 | BA, J, P, V (S, A, G, M) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 5 | CA, DA, EA, K, L... (S, A, G, M) | 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID | non-polymer | 558.6 | 12 | Chemie (117) | |||
| 6 | FA, N, T, Z (S, A, G, M) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
B, H, N, T: 1 - 108 (UniProt: P68106)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 2311917.5 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 7902.4 | |
| All* | Total formula weight | 2319819.9 |
