9OIQ

The von Hippel Lindau-ElonginB-ElonginC (VCB) complex with fragment 15

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, J (A, J)	Elongin-B	polymer	104	11852.4	2	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, E (B, E)	Elongin-C	polymer	98	11135.6	2	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C, I, L (C, I, L)	von Hippel-Lindau disease tumor suppressor	polymer	180	20729.5	3	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (human)	Protein G7,pVHL
4	D (D)	Elongin-B	polymer	104	11748.4	1	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
5	F (F)	von Hippel-Lindau disease tumor suppressor	polymer	180	20833.5	1	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (human)	Protein G7,pVHL
6	G (G)	Elongin-B	polymer	104	11852.4	1	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
7	H, K (H, K)	Elongin-C	polymer	98	11031.7	2	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
8	M, N (I, L)	2-(5-amino-1H-1,3-benzimidazol-1-yl)ethan-1-ol	non-polymer		177.2	2	Chemie (A1CBM)	Homo sapiens
9	O, P, Q, R, S... (A, B, C, E, F...)	water	water		18.0	23	Chemie (HOH)

Sequence modifications

B, E: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 15	-	initiating methionine
Gly 16	-	expression tag

C, I, L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Met 34	-	expression tag
Gly 35	-	expression tag
Ser 36	-	expression tag
Ser 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
Ser 44	-	expression tag
Ser 45	-	expression tag
Gly 46	-	expression tag
Leu 47	-	expression tag
Val 48	-	expression tag
Pro 49	-	expression tag
Arg 50	-	expression tag
Gly 51	-	expression tag
Ser 52	-	expression tag
His 53	-	expression tag

F: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Met 34	-	initiating methionine
Gly 35	-	expression tag
Ser 36	-	expression tag
Ser 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
Ser 44	-	expression tag
Ser 45	-	expression tag
Gly 46	-	expression tag
Leu 47	-	expression tag
Val 48	-	expression tag
Pro 49	-	expression tag
Arg 50	-	expression tag
Gly 51	-	expression tag
Ser 52	-	expression tag
His 53	-	expression tag

H, K: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 15	-	initiating methionine
Gly 16	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	174662.3
Non-Polymers*	Number of molecules	2
	Total formula weight	354.4
All*	Total formula weight	175016.7

*Water molecules are not included.