Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Protein cereblon | polymer | 111 | 12309.1 | 4 | UniProt (Q96SW2) Pfam (PF03226) | Homo sapiens (human) | |
| 2 | B, D, F, H (B, D, F, H) | Zinc finger protein Helios | polymer | 30 | 3300.8 | 4 | UniProt (Q9UKS7) Pfam (PF00096) | Homo sapiens (human) | Ikaros family zinc finger protein 2 |
| 3 | I, L, O, R (A, C, E, G) | (3S)-3-[(5M)-5-{1-(oxetan-3-yl)-4-[(pyrrolidin-1-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-6-yl}-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione | non-polymer | 499.6 | 4 | Chemie (A1CBG) | |||
| 4 | J, K, M, N, P... (A, B, C, D, E...) | ZINC ION | non-polymer | 65.4 | 9 | Chemie (ZN) | |||
| 5 | AA, BA, CA, V, W... (F, G, H, A, B...) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 319 - 426 (UniProt: Q96SW2)
B, D, F, H: 136 - 164 (UniProt: Q9UKS7)
| PDB | External Database | Details |
|---|---|---|
| Gly 316 | - | expression tag |
| Pro 317 | - | expression tag |
| Ser 318 | - | expression tag |
| Ser 322 | Cys 322 | conflict |
| Ser 343 | Cys 343 | conflict |
| Ser 366 | Cys 366 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 135 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 62439.3 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2586.9 | |
| All* | Total formula weight | 65026.2 |
