9OHN

Cryo-EM structure of human p97/VCP bound to inhibitor GND-135

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Transitional endoplasmic reticulum ATPase	polymer	821	91212.6	12	UniProt (P55072) Pfam (PF02359) Pfam (PF02933) Pfam (PF00004) Pfam (PF17862)	Homo sapiens (human)	TER ATPase,15S Mg(2+)-ATPase p97 subunit,Valosin-containing protein,VCP
2	AA, CA, EA, GA, IA... (H, I, J, K, L...)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	12	Chemie (ADP)
3	BA, DA, FA, HA, JA... (H, I, J, K, L...)	(1P)-1-{4-(benzylamino)-2-methyl-1-[2-(morpholin-4-yl)-2-oxoethyl]-1H-pyrrolo[2,3-b]pyridin-6-yl}-2-methyl-1H-indole-4-carboxamide	non-polymer		536.6	12	Chemie (A1CBF)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 2 - 806 (UniProt: P55072)

PDB	External Database	Details
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Ser -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Gly 1	-	expression tag
His 155	Arg 155	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	1094551.2
Non-Polymers*	Number of molecules	24
	Total formula weight	11565.9
All*	Total formula weight	1106117.1

*Water molecules are not included.