9OGU
HIV-1 Env BG505 SOSIP.664-dPG-His in complex with PGT122 and 3BNC117 Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, F (A, E, C) | HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp120 | polymer | 516 | 57946.0 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | |
| 2 | B, C, D (F, D, B) | Envelope glycoprotein gp160 | polymer | 168 | 18596.8 | 3 | UniProt (A0A6H1VYE9) UniProt (by SIFTS) (A0ABF7PQ88) | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | G, K, O (H, M, P) | 3BNC117 Fab heavy chain | polymer | 226 | 24656.5 | 3 | Homo sapiens (human) | ||
| 4 | H, L, P (I, L, Q) | 3BNC117 Fab light chain | polymer | 206 | 23022.7 | 3 | Homo sapiens (human) | ||
| 5 | I, M, Q (J, N, R) | PGT122 Fab heavy chain | polymer | 235 | 25434.7 | 3 | Homo sapiens (human) | ||
| 6 | J, N, R (K, O, S) | PGT122 Fab light chain | polymer | 211 | 22712.1 | 3 | Homo sapiens (human) | ||
| 7 | AA, BA, GA, HA, JA... (a, b, g, h, j...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 11 | In PDB GlyTouCan (G42666HT) | |||
| 8 | U (U) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 9 | V (V) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 10 | KA, Y (k, Y) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 11 | FA, IA, RA, Z (f, i, r, Z) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
| 12 | CA, DA, LA, PA (c, d, l, p) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 13 | EA, OA (e, o) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G46836GH) | |||
| 14 | MA (m) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 383.3 | 1 | In PDB GlyTouCan (G90333CG) | |||
| 15 | AB, BB, CB, DB, EB... (A, F, D, B, E...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 28 | Chemie (NAG) |
Sequence modifications
A, E, C: 31 - 508 (UniProt: Q2N0S6)
F, D, B: 512 - 664 (UniProt: A0A6H1VYE9)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Lys 0 | - | expression tag |
| Arg 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Cys 4 | - | expression tag |
| Cys 5 | - | expression tag |
| Val 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Cys 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Val 13 | - | expression tag |
| Phe 14 | - | expression tag |
| Val 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Ile 21 | - | expression tag |
| His 22 | - | expression tag |
| Ala 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Phe 25 | - | expression tag |
| Arg 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Arg 30 | - | expression tag |
| Asn 332 | Thr 330 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
| Arg 509 | - | expression tag |
| Arg 510 | - | expression tag |
| Arg 511 | - | expression tag |
| Arg 512 | - | expression tag |
| Arg 513 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro 560 | Ile 556 | conflict |
| - | Leu 562 | deletion |
| Pro 567 | Lys 564 | engineered mutation |
| Gly 568 | Leu 565 | engineered mutation |
| Cys 605 | Thr 602 | conflict |
| Gly 665 | - | expression tag |
| Ser 666 | - | expression tag |
| Gly 667 | - | expression tag |
| Ser 668 | - | expression tag |
| Gly 669 | - | expression tag |
| Gly 670 | - | expression tag |
| Ser 671 | - | expression tag |
| Gly 672 | - | expression tag |
| His 673 | - | expression tag |
| His 674 | - | expression tag |
| His 675 | - | expression tag |
| His 676 | - | expression tag |
| His 677 | - | expression tag |
| His 678 | - | expression tag |
| His 679 | - | expression tag |
| His 680 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 517106.1 | |
| Branched | Number of molecules | 26 |
| Total formula weight | 16830.4 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 6193.8 | |
| All* | Total formula weight | 540130.4 |
