9OGJ

Structure of TEAD2 bound to G2181

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transcriptional enhancer factor TEF-4	polymer	250	28515.1	2	UniProt (Q15562) Pfam (PF17725)	Homo sapiens (human)	TEA domain family member 2,TEAD-2
2	C, D (A, B)	2-fluoro-1-(3-{4-(hydroxymethyl)-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}azetidin-1-yl)prop-2-en-1-one	non-polymer		436.4	2	Chemie (A1CA6)
3	E, F (A, B)	water	water		18.0	41	Chemie (HOH)

Sequence modifications

A, B: 217 - 447 (UniProt: Q15562)

PDB	External Database	Details
Met 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag
Gly 208	-	expression tag
Glu 209	-	expression tag
Asn 210	-	expression tag
Leu 211	-	expression tag
Tyr 212	-	expression tag
Phe 213	-	expression tag
Gln 214	-	expression tag
Gly 215	-	expression tag
Ser 216	-	expression tag
Gly 448	-	expression tag
Asn 449	-	expression tag
Ser 450	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57030.2
Non-Polymers*	Number of molecules	2
	Total formula weight	872.7
All*	Total formula weight	57903.0

*Water molecules are not included.