9OGB
Cryo-EM structure of human exportin-1 conjugated with selinexor and bound to yeast RAN-GTP and human ASB8-ELOB/C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Exportin-1 | polymer | 1073 | 123662.5 | 1 | UniProt (O14980) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) | Homo sapiens (human) | Exp1,Chromosome region maintenance 1 protein homolog |
| 2 | B (B) | GTP-binding nuclear protein GSP1/CNR1 | polymer | 181 | 20561.7 | 1 | UniProt (P32835) Pfam (PF00071) | Saccharomyces cerevisiae (brewer's yeast) | Chromosome stability protein 17,GTPase Ran homolog,Genetic suppressor of PRP20-1 |
| 3 | C (C) | Ankyrin repeat and SOCS box protein 8 | polymer | 274 | 29869.2 | 1 | UniProt (Q9H765) Pfam (PF07525) Pfam (PF12796) | Homo sapiens (human) | ASB-8 |
| 4 | D (E) | Elongin-C | polymer | 97 | 10974.6 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 5 | E (F) | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 6 | F (A) | selinexor, bound form | non-polymer | 445.3 | 1 | Chemie (V6A) PubChem (155136071) | |||
| 7 | G (B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 8 | H (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) |
Sequence modifications
A: 1 - 1071 (UniProt: O14980)
B: 1 - 179 (UniProt: P32835)
C: 17 - 288 (UniProt: Q9H765)
E: 17 - 112 (UniProt: Q15369)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 71 | Gln 71 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 198215.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 992.8 | |
| All* | Total formula weight | 199208.6 |
