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9OG3

Crystal structure of WRN in complex with compound 4

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRNpolymer42448233.81UniProt (Q14191)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF16124)
Homo sapiens (human)DNA helicase,RecQ-like type 3,RecQ protein-like 2,Werner syndrome protein
2B
(A)
(3R,4S)-N-[(2R)-3-cyclohexyl-1-(dimethylamino)-1-oxopropan-2-yl]-1-[(2-fluoro-4-methylphenyl)acetyl]-4-[3-(2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)propanamido]piperidine-3-carboxamidenon-polymer662.81Chemie (A1CA4)
3C
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
4D
(A)
waterwater18.0155Chemie (HOH)
Sequence modifications
A: 526 - 946 (UniProt: Q14191)
PDBExternal DatabaseDetails
Ser 523-expression tag
Gly 524-expression tag
Ser 525-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight48233.8
Non-Polymers*Number of molecules2
Total formula weight728.2
All*Total formula weight48962.0
*Water molecules are not included.

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