9OFO

HCoV-229E S2P bound by three DH1533 Fabs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Surface glycoprotein	polymer	1134	123593.9	3	UniProt (A0A1B3TN99)	Human coronavirus 229E
2	D, F, H (H, M, O)	DH1533 FAB heavy chain	polymer	239	25302.3	3		Homo sapiens (human)
3	E, G, I (L, N, P)	DH1533 FAB light chain	polymer	214	23424.9	3		Homo sapiens (human)
4	DA, J, T (d, D, T)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	3	In PDB GlyTouCan (G22768VO)
5	AA, EA, GA, HA, K... (a, e, g, h, E...)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	12	In PDB GlyTouCan (G15407YE)
6	BA, CA, FA, IA, JA... (b, c, f, i, j...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	15	In PDB GlyTouCan (G42666HT)
7	AB, AC, BB, BC, CB... (A, C, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	45	Chemie (NAG)

Sequence modifications

A, B, C: 1 - 1054 (UniProt: A0A1B3TN99)

PDB	External Database	Details
Pro 869	Ile 869	conflict
Pro 870	Ile 870	conflict
Gly 1055	-	expression tag
Ser 1056	-	expression tag
Gly 1057	-	expression tag
Tyr 1058	-	expression tag
Ile 1059	-	expression tag
Pro 1060	-	expression tag
Glu 1061	-	expression tag
Ala 1062	-	expression tag
Pro 1063	-	expression tag
Arg 1064	-	expression tag
Asp 1065	-	expression tag
Gly 1066	-	expression tag
Gln 1067	-	expression tag
Ala 1068	-	expression tag
Tyr 1069	-	expression tag
Val 1070	-	expression tag
Arg 1071	-	expression tag
Lys 1072	-	expression tag
Asp 1073	-	expression tag
Gly 1074	-	expression tag
Glu 1075	-	expression tag
Trp 1076	-	expression tag
Val 1077	-	expression tag
Leu 1078	-	expression tag
Leu 1079	-	expression tag
Ser 1080	-	expression tag
Thr 1081	-	expression tag
Phe 1082	-	expression tag
Leu 1083	-	expression tag
Gly 1084	-	expression tag
Arg 1085	-	expression tag
Ser 1086	-	expression tag
Leu 1087	-	expression tag
Glu 1088	-	expression tag
Val 1089	-	expression tag
Leu 1090	-	expression tag
Phe 1091	-	expression tag
Gln 1092	-	expression tag
Gly 1093	-	expression tag
Pro 1094	-	expression tag
Gly 1095	-	expression tag
His 1096	-	expression tag
His 1097	-	expression tag
His 1098	-	expression tag
His 1099	-	expression tag
His 1100	-	expression tag
His 1101	-	expression tag
His 1102	-	expression tag
His 1103	-	expression tag
Ser 1104	-	expression tag
Ala 1105	-	expression tag
Trp 1106	-	expression tag
Ser 1107	-	expression tag
His 1108	-	expression tag
Pro 1109	-	expression tag
Gln 1110	-	expression tag
Phe 1111	-	expression tag
Glu 1112	-	expression tag
Lys 1113	-	expression tag
Gly 1114	-	expression tag
Gly 1115	-	expression tag
Gly 1116	-	expression tag
Ser 1117	-	expression tag
Gly 1118	-	expression tag
Gly 1119	-	expression tag
Gly 1120	-	expression tag
Gly 1121	-	expression tag
Ser 1122	-	expression tag
Gly 1123	-	expression tag
Gly 1124	-	expression tag
Ser 1125	-	expression tag
Ala 1126	-	expression tag
Trp 1127	-	expression tag
Ser 1128	-	expression tag
His 1129	-	expression tag
Pro 1130	-	expression tag
Gln 1131	-	expression tag
Phe 1132	-	expression tag
Glu 1133	-	expression tag
Lys 1134	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	516963.1
Branched	Number of molecules	30
	Total formula weight	16137.0
Non-Polymers*	Number of molecules	45
	Total formula weight	9954.4
All*	Total formula weight	543054.4

*Water molecules are not included.