9OEM

GluN1/GluN3A_ELSL in complex with CGP/Gly/GNE/UCM, in pre-open conformation (class 1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Isoform E of Glutamate receptor ionotropic, NMDA 1	polymer	870	97874.0	2	UniProt (P35439)	Rattus norvegicus (Norway rat)	GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1
2	B, D (B, D)	Glutamate receptor ionotropic, NMDA 3A	polymer	993	110729.2	2	UniProt (Q9R1M7)	Rattus norvegicus (Norway rat)	GluN3A,Glutamate receptor chi-1,N-methyl-D-aspartate receptor,N-methyl-D-aspartate receptor subtype 3A,NMDAR3A,NR3A,NMDAR-L,NMDAR-L1
3	E, F (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	G, H, K, L, P... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG) PubChem (24139)
5	I, R (A, C)	[(1S)-1-[[7-bromanyl-2,3-bis(oxidanylidene)-1,4-dihydroquinoxalin-5-yl]methylamino]ethyl]phosphonic acid	non-polymer		378.1	2	Chemie (J86) PubChem (6604872)
6	J, T (B, D)	GLYCINE	non-polymer		75.1	2	Chemie (GLY) PubChem (750)
7	M, N, O, S, W... (B, C, D)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	6	Chemie (Y01) PubChem (65082)

Sequence modifications

A, C: 1 - 847 (UniProt: P35439)

PDB	External Database	Details
Leu 848	-	expression tag
Val 849	-	expression tag
Pro 850	-	expression tag
Arg 851	-	expression tag
Gly 852	-	expression tag
Ser 853	-	expression tag
Ala 854	-	expression tag
Ala 855	-	expression tag
Ala 856	-	expression tag
Ala 857	-	expression tag
Ser 858	-	expression tag
Gly 859	-	expression tag
Leu 860	-	expression tag
Arg 861	-	expression tag
Ser 862	-	expression tag
His 863	-	expression tag
His 864	-	expression tag
His 865	-	expression tag
His 866	-	expression tag
His 867	-	expression tag
His 868	-	expression tag
His 869	-	expression tag
His 870	-	expression tag

B, D: 1 - 970 (UniProt: Q9R1M7)

PDB	External Database	Details
Leu 889	Glu 889	engineered mutation
Leu 892	Ser 892	engineered mutation
Leu 971	-	expression tag
Val 972	-	expression tag
Pro 973	-	expression tag
Arg 974	-	expression tag
Gly 975	-	expression tag
Ser 976	-	expression tag
Ala 977	-	expression tag
Ala 978	-	expression tag
Ala 979	-	expression tag
Ala 980	-	expression tag
Ser 981	-	expression tag
Gly 982	-	expression tag
Leu 983	-	expression tag
Arg 984	-	expression tag
Ser 985	-	expression tag
Trp 986	-	expression tag
Ser 987	-	expression tag
His 988	-	expression tag
Pro 989	-	expression tag
Gln 990	-	expression tag
Phe 991	-	expression tag
Glu 992	-	expression tag
Lys 993	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	417206.4
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	18
	Total formula weight	5596.4
All*	Total formula weight	423651.6

*Water molecules are not included.