9OBI
Room Temperature X-Ray Structure of HIV-1 Protease in Complex with Inhibitor GRL-075-24A
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Protease | polymer | 99 | 10740.7 | 8 | UniProt (Q5RZ08) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | I, J, K, M (B, D, E, G) | (1S,5S,7S)-7-(2-methoxyphenyl)-8-oxaspiro[4.5]decan-1-yl {(2S,3R)-3-hydroxy-4-[(4-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate | non-polymer | 694.9 | 4 | Chemie (A1CAJ) | |||
| 3 | L, N (E, G) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 493 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 99 (UniProt: Q5RZ08)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Ile 33 | Leu 33 | engineered mutation |
| Ile 63 | Leu 63 | engineered mutation |
| Ala 67 | Cys 67 | engineered mutation |
| Ala 95 | Cys 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 85925.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2850.4 | |
| All* | Total formula weight | 88775.8 |
