9O8W
Crystal structure of an MKP5 mutant, Y435F, in complex with an allosteric inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Dual specificity protein phosphatase 10 | polymer | 149 | 17151.7 | 6 | UniProt (Q9Y6W6) Pfam (PF00782) | Homo sapiens (human) | Mitogen-activated protein kinase phosphatase 5,MAP kinase phosphatase 5,MKP-5 |
| 2 | G, H, I, J, L... (A, B, C, D, E...) | 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one | non-polymer | 364.5 | 6 | Chemie (CJA) | |||
| 3 | K, N (D, F) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 320 - 467 (UniProt: Q9Y6W6)
| PDB | External Database | Details |
|---|---|---|
| Met 319 | - | initiating methionine |
| Phe 435 | Tyr 435 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 102910.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2379.4 | |
| All* | Total formula weight | 105289.5 |
