9O69
Crystal Structure of human Cathepsin K co-crystalized with Nirmatrelvir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cathepsin K | polymer | 215 | 23523.5 | 1 | UniProt (P43235) | Homo sapiens (human) | Cathepsin O,Cathepsin O2,Cathepsin X |
| 2 | B (A) | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide | non-polymer | 501.5 | 1 | Chemie (4WI) | |||
| 3 | C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | E (A) | water | water | 18.0 | 245 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23523.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 625.7 | |
| All* | Total formula weight | 24149.2 |
