9O5O

Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to a small molecule activator

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F, G, H (A, B, C, D)	Intermediate conductance calcium-activated potassium channel protein 4,Small conductance calcium-activated potassium channel protein 2 chimera	polymer	435	49382.2	4	UniProt (O15554) UniProt (Q9H2S1) Pfam (PF03530) Pfam (PF07885) Pfam (PF02888)	Homo sapiens (human)	SKCa 4,SKCa4,hSK4,Gardos channel,IKCa1,hIK1,KCa3.1,Putative Gardos channel,hKCa4,SK2,SKCa 2,SKCa2,KCa2.2
2	B, C, D, E (E, F, G, H)	Calmodulin-1	polymer	149	16852.5	4	UniProt (P0DP23) Pfam (PF13499)	Homo sapiens (human)
3	BA, CA, DA, I (B, C, D, A)	N-(2,1,3-benzoxadiazol-4-yl)-4-(trifluoromethyl)benzamide	non-polymer		307.2	4	Chemie (A1B8G)
4	J, K (A)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
5	AA, L, M, N, O... (H, E, F, G)	CALCIUM ION	non-polymer		40.1	16	Chemie (CA)

Sequence modifications

A, B, C, D: 110 - 123 (UniProt: O15554)
A, B, C, D: 124 - 412 (UniProt: Q9H2S1)
A, B, C, D: 413 - 535 (UniProt: O15554)

PDB	External Database	Details
Ser 536	-	expression tag
Ser 537	-	expression tag
Ser 538	-	expression tag
Leu 539	-	expression tag
Glu 540	-	expression tag
Val 541	-	expression tag
Leu 542	-	expression tag
Phe 543	-	expression tag
Gln 544	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	264938.8
Non-Polymers*	Number of molecules	22
	Total formula weight	1948.4
All*	Total formula weight	266887.2

*Water molecules are not included.