9O5D

The KICSTOR-GATOR1-SAMTOR complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (D)	GATOR complex protein NPRL2	polymer	401	45799.5	1	UniProt (Q8WTW4) Pfam (PF06218)	Homo sapiens (human)	Gene 21 protein,G21 protein,Nitrogen permease regulator 2-like protein,NPR2-like protein,Tumor suppressor candidate 4
2	B (B)	GATOR1 complex protein DEPDC5	polymer	1621	183207.7	1	UniProt (O75140) Pfam (PF23013) Pfam (PF12257) Pfam (PF00610) Pfam (PF19418)	Homo sapiens (human)	DEP domain-containing protein 5
3	C (A)	S-adenosylmethionine sensor upstream of mTORC1	polymer	420	47809.1	1	UniProt (Q1RMZ1) Pfam (PF11968)	Homo sapiens (human)	Probable methyltransferase BMT2 homolog
4	D (C)	GATOR complex protein NPRL3	polymer	590	65769.0	1	UniProt (Q12980) Pfam (PF03666) Pfam (PF24064)	Homo sapiens (human)	-14 gene protein,Alpha-globin regulatory element-containing gene protein,Nitrogen permease regulator 3-like protein,Protein CGTHBA
5	E (E)	KICSTOR complex protein SZT2	polymer	1349	149178.5	1	UniProt (Q5T011)	Homo sapiens (human)	Seizure threshold 2 protein homolog

Sequence modifications

D: 1 - 380 (UniProt: Q8WTW4)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Tyr -18	-	expression tag
Pro -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Val -14	-	expression tag
Pro -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Ala -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Asn -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

B: 1 - 1603 (UniProt: O75140)

PDB	External Database	Details
Met -17	-	expression tag
Gly -16	-	expression tag
Asp -15	-	expression tag
Tyr -14	-	expression tag
Lys -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

A: 1 - 405 (UniProt: Q1RMZ1)

PDB	External Database	Details
Gly 406	-	expression tag
Gly 407	-	expression tag
Gly 408	-	expression tag
Ser 409	-	expression tag
Gly 410	-	expression tag
Gly 411	-	expression tag
Gly 412	-	expression tag
Asp 413	-	expression tag
Tyr 414	-	expression tag
Lys 415	-	expression tag
Asp 416	-	expression tag
Asp 417	-	expression tag
Asp 418	-	expression tag
Asp 419	-	expression tag
Lys 420	-	expression tag

C: 1 - 569 (UniProt: Q12980)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Tyr -18	-	expression tag
Pro -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Val -14	-	expression tag
Pro -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Ala -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Asn -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

E: 1 - 1330 (UniProt: Q5T011)

PDB	External Database	Details
Met -18	-	expression tag
Glu -17	-	expression tag
Met -16	-	expression tag
Asp -15	-	expression tag
Tyr -14	-	expression tag
Lys -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	491763.9
All*	Total formula weight	491763.9

*Water molecules are not included.