9O54
ADAM17 Prodomain-Metalloproteinase Domains bound to MEDI3622 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Disintegrin and metalloproteinase domain-containing protein 17 | polymer | 483 | 55163.0 | 1 | UniProt (P78536) Pfam (PF13574) | Homo sapiens (human) | ADAM 17,Snake venom-like protease,TNF-alpha convertase,TNF-alpha-converting enzyme |
| 2 | B (C) | MEDI3622 Fab Light Chain | polymer | 214 | 23324.9 | 1 | Homo sapiens (human) | ||
| 3 | C (D) | MEDI3622 Fab Heavy Chain | polymer | 223 | 23658.6 | 1 | Homo sapiens (human) | ||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 1 - 477 (UniProt: P78536)
| PDB | External Database | Details |
|---|---|---|
| Ala 58 | Arg 58 | engineered mutation |
| Gln 174 | Asn 174 | engineered mutation |
| Ala 211 | Arg 211 | engineered mutation |
| Ala 214 | Arg 214 | engineered mutation |
| His 478 | - | expression tag |
| His 479 | - | expression tag |
| His 480 | - | expression tag |
| His 481 | - | expression tag |
| His 482 | - | expression tag |
| His 483 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 102146.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 102211.8 |
