9O53

Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to a small molecule inhibitor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Intermediate conductance calcium-activated potassium channel protein 4,Small conductance calcium-activated potassium channel protein 2 chimera	polymer	435	49382.2	4	UniProt (O15554) UniProt (Q9H2S1) Pfam (PF03530) Pfam (PF07885) Pfam (PF02888)	Homo sapiens (human)	SKCa 4,SKCa4,hSK4,Gardos channel,IKCa1,hIK1,KCa3.1,Putative Gardos channel,hKCa4,SK2,SKCa 2,SKCa2,KCa2.2
2	E, F, G, H (E, F, G, H)	Calmodulin-1	polymer	149	16852.5	4	UniProt (P0DP23) Pfam (PF13499)	Homo sapiens (human)
3	I, N, O, P (A, B, C, D)	N-(2,1,3-benzoxadiazol-4-yl)-3-(4-methoxybenzene-1-sulfonamido)benzamide	non-polymer		424.4	4	Chemie (A1B8D)
4	J, K, L, M (A)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
5	AA, BA, CA, DA, EA... (G, H, E, F)	CALCIUM ION	non-polymer		40.1	16	Chemie (CA)

Sequence modifications

A, B, C, D: 110 - 123 (UniProt: O15554)
A, B, C, D: 124 - 412 (UniProt: Q9H2S1)
A, B, C, D: 413 - 535 (UniProt: O15554)

PDB	External Database	Details
Ser 536	-	expression tag
Ser 537	-	expression tag
Ser 538	-	expression tag
Leu 539	-	expression tag
Glu 540	-	expression tag
Val 541	-	expression tag
Leu 542	-	expression tag
Phe 543	-	expression tag
Gln 544	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	264938.8
Non-Polymers*	Number of molecules	24
	Total formula weight	2495.4
All*	Total formula weight	267434.2

*Water molecules are not included.