9O52
Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to the bee toxin apamin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Intermediate conductance calcium-activated potassium channel protein 4,Small conductance calcium-activated potassium channel protein 2 chimera | polymer | 435 | 49382.2 | 4 | UniProt (O15554) UniProt (Q9H2S1) Pfam (PF03530) Pfam (PF07885) Pfam (PF02888) | Homo sapiens (human) | SKCa 4,SKCa4,hSK4,Gardos channel,IKCa1,hIK1,KCa3.1,Putative Gardos channel,hKCa4,SK2,SKCa 2,SKCa2,KCa2.2 |
| 2 | E, F, G, H (E, F, G, H) | Calmodulin-1 | polymer | 149 | 16852.5 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | I (I) | Apamin | polymer | 18 | 2036.4 | 1 | UniProt (P01500) Pfam (PF17454) | Apis mellifera (honey bee) | APM,Apamine |
| 4 | J, K, L, M (A, D) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 5 | AA, BA, CA, N, O... (H, E, F, G) | CALCIUM ION | non-polymer | 40.1 | 16 | Chemie (CA) |
Sequence modifications
A, B, C, D: 110 - 123 (UniProt: O15554)
A, B, C, D: 124 - 412 (UniProt: Q9H2S1)
A, B, C, D: 413 - 535 (UniProt: O15554)
A, B, C, D: 124 - 412 (UniProt: Q9H2S1)
A, B, C, D: 413 - 535 (UniProt: O15554)
| PDB | External Database | Details |
|---|---|---|
| Ser 536 | - | expression tag |
| Ser 537 | - | expression tag |
| Ser 538 | - | expression tag |
| Leu 539 | - | expression tag |
| Glu 540 | - | expression tag |
| Val 541 | - | expression tag |
| Leu 542 | - | expression tag |
| Phe 543 | - | expression tag |
| Gln 544 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 266975.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 797.6 | |
| All* | Total formula weight | 267772.9 |
