9O2L

Heparanase P6 in complex with fragment C17

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Heparanase 50 kDa subunit	polymer	384	42986.3	1	UniProt (Q9Y251)	Homo sapiens (human)
2	B (B)	Heparanase 8 kDa subunit	polymer	74	8273.5	1	UniProt (Q9Y251)	Homo sapiens (human)
3	C (A)	2-(chloromethyl)-1H-benzimidazole	non-polymer		166.6	1	Chemie (AQF)
4	D (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	E (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
6	F, G, H, I (A)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
7	J, K (A, B)	water	water		18.0	233	Chemie (HOH)

Sequence modifications

A: 160 - 543 (UniProt: Q9Y251)

PDB	External Database	Details
Lys 178	Asn 178	conflict
Ser 195	Ala 195	conflict
Gly 197	Leu 197	conflict
Ala 212	Ser 212	conflict
Asp 219	Ser 219	conflict
Arg 230	Leu 230	conflict
Gly 234	Asp 234	conflict
Lys 244	Glu 244	conflict
His 248	Gln 248	conflict
Gly 273	Arg 273	conflict
Ala 292	Ser 292	conflict
Leu 307	Lys 307	conflict
Thr 318	Ile 318	conflict
Gln 322	Ser 322	conflict
Leu 327	Phe 327	conflict
Gly 354	Leu 354	conflict
Gln 426	Ser 426	conflict
Asp 427	Lys 427	conflict
Gln 477	Lys 477	conflict
His 483	Leu 483	conflict
Asp 486	His 486	conflict
Gln 498	Leu 498	conflict
Lys 512	Met 512	conflict
Pro 513	Glu 513	conflict
Ala 530	Ser 530	conflict
Pro 540	Ala 540	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51259.8
Non-Polymers*	Number of molecules	7
	Total formula weight	719.0
All*	Total formula weight	51978.9

*Water molecules are not included.