9O16
Crystal Structure of human BCL-2 (R129L) mutant in complex with a stapled BAD BH3 peptide BAD SAHB 4.2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Apoptosis regulator Bcl-2,Bcl-2-like protein 1 | polymer | 166 | 19313.5 | 1 | UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (human) | Bcl2-L-1,Apoptosis regulator Bcl-X |
| 2 | B (B) | stapled BAD BH3 peptide BAD SAHB 4.2 | polymer | 23 | 2781.2 | 1 | UniProt (by SIFTS) (Q92934) | Homo sapiens | |
| 3 | C, G (A, B) | IMIDAZOLE | non-polymer | 69.1 | 2 | Chemie (IMD) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F, H (A, B) | NICKEL (II) ION | non-polymer | 58.7 | 3 | Chemie (NI) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A: 1 - 75 (UniProt: P10415)
A: 76 - 91 (UniProt: Q07817)
A: 92 - 207 (UniProt: P10415)
A: 76 - 91 (UniProt: Q07817)
A: 92 - 207 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Leu 129 | Arg 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22094.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 410.3 | |
| All* | Total formula weight | 22505.0 |
