9O0Y
Co-crystal structure of human TREX1 in complex with an inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Three-prime repair exonuclease 1 | polymer | 234 | 25169.9 | 3 | UniProt (Q9NSU2) | Homo sapiens (human) | 3'-5' exonuclease TREX1,Deoxyribonuclease III,DNase III |
| 2 | D, I, N (A, B, C) | N-[(2,3-dichlorophenyl)methyl]-3,5-difluoro-N-[(pyridin-3-yl)methyl]benzamide | non-polymer | 407.2 | 3 | Chemie (A1B7T) | |||
| 3 | E, J, O (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | F, K, P, Q (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 5 | G, H, L, M, R... (A, B, C) | UNKNOWN ATOM OR ION | non-polymer | 6 | Chemie (UNX) | ||||
| 6 | T, U, V (A, B, C) | water | water | 18.0 | 499 | Chemie (HOH) |
Sequence modifications
A, B, C: 5 - 238 (UniProt: Q9NSU2)
| PDB | External Database | Details |
|---|---|---|
| His 8 | Pro 8 | conflict |
| His 10 | Pro 10 | conflict |
| Ser 26 | Phe 26 | conflict |
| Arg 28 | Gln 28 | conflict |
| Glu 30 | Lys 30 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 75509.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1542.9 | |
| All* | Total formula weight | 77052.5 |
