9O0R
Crystal structure of wild-type KRAS (GDP-bound) in complex with MRTX849 (adagrasib)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GTPase KRas | polymer | 170 | 19328.8 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | C, I (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 3 | D, G, H, J, M... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | E, K (A, B) | Adagrasib | non-polymer | 604.1 | 2 | Chemie (A1B7W) PubChem (138611145) PubChem (148888812) PubChem (155321704) PubChem (165173784) PubChem (138611346) PubChem (139455463) | |||
| 5 | F, L (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) PubChem (175) | |||
| 6 | O, P (A, B) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38657.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2605.2 | |
| All* | Total formula weight | 41262.8 |
