9O0R
Crystal structure of wild-type KRAS (GDP-bound) in complex with MRTX849 (adagrasib)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GTPase KRas | polymer | 170 | 19328.8 | 2 | UniProt (P01116) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | C, I (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 3 | D, G, H, J, M... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | E, K (A, B) | Adagrasib | non-polymer | 604.1 | 2 | Chemie (A1B7W) | |||
| 5 | F, L (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | O, P (A, B) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38657.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2605.2 | |
| All* | Total formula weight | 41262.8 |
