9O0P
Crystal structure of GDP-bound mutant MRAS in complex with MRTX1133
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ras-related protein M-Ras | polymer | 179 | 20469.2 | 2 | UniProt (O14807) Pfam (PF00071) | Homo sapiens (human) | Ras-related protein R-Ras3 |
| 2 | C, G (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 3 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | E, H (A, B) | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol | non-polymer | 600.6 | 2 | Chemie (6IC) | |||
| 5 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 367 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 178 (UniProt: O14807)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Tyr 74 | Phe 74 | engineered mutation |
| His 105 | Arg 105 | engineered mutation |
| Tyr 106 | Phe 106 | engineered mutation |
| Gln 109 | Leu 109 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40938.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2147.4 | |
| All* | Total formula weight | 43085.9 |
