9O0P
Crystal structure of GDP-bound mutant MRAS in complex with MRTX1133
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ras-related protein M-Ras | polymer | 179 | 20469.2 | 2 | UniProt (O14807) Pfam (PF00071) | Homo sapiens (human) | Ras-related protein R-Ras3 |
| 2 | C, G (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 3 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | E, H (A, B) | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol | non-polymer | 600.6 | 2 | Chemie (6IC) PubChem (177366592) PubChem (162369732) PubChem (166603898) PubChem (166607374) PubChem (169273440) PubChem (169410089) PubChem (171346253) PubChem (172156090) PubChem (156124857) PubChem (166080707) PubChem (169041315) | |||
| 5 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 367 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 178 (UniProt: O14807)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Tyr 74 | Phe 74 | engineered mutation |
| His 105 | Arg 105 | engineered mutation |
| Tyr 106 | Phe 106 | engineered mutation |
| Gln 109 | Leu 109 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40938.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2147.4 | |
| All* | Total formula weight | 43085.9 |
