9NYZ
Crystal structure of DCKA/glutamate-bound GluN1/GluN2A agonist binding domains with UCM-101
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate receptor ionotropic, NMDA 1 | polymer | 292 | 33340.0 | 1 | UniProt (P35439) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B (B) | Glutamate receptor ionotropic, NMDA 2A | polymer | 283 | 31785.3 | 1 | UniProt (Q00959) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NMDAR2A,NR2A |
| 3 | C (A) | 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID | non-polymer | 258.1 | 1 | Chemie (DK1) | |||
| 4 | D (B) | N-(cyclohexylmethyl)-2-[(5-{[(1R)-1-phenylpropyl]amino}-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide | non-polymer | 404.6 | 1 | Chemie (A1B7E) | |||
| 5 | E (B) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 497 | Chemie (HOH) |
Sequence modifications
A: 2 - 152 (UniProt: P35439)
A: 155 - 292 (UniProt: P35439)
B: 5 - 142 (UniProt: Q00959)
B: 145 - 286 (UniProt: Q00959)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 153 | - | linker |
| Thr 154 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 4 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 143 | - | linker |
| Thr 144 | - | linker |
| Thr 242 | Ser 758 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65125.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 809.8 | |
| All* | Total formula weight | 65935.1 |
