9NYR
Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 24
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | Cyclin-dependent kinase 2 | polymer | 298 | 34056.5 | 1 | UniProt (P24941) | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B (E) | G1/S-specific cyclin-E1 | polymer | 286 | 33140.6 | 1 | UniProt (P24864) | Homo sapiens (human) | |
| 3 | C (A) | DNA damage-binding protein 1 | polymer | 1148 | 128139.6 | 1 | UniProt (Q16531) | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 4 | D (B) | Protein cereblon | polymer | 405 | 46465.4 | 1 | UniProt (Q96SW2) | Homo sapiens (human) | |
| 5 | E (D) | N-{(1R,4S)-4-[(4-{3-chloro-4-[(3R)-2,6-dioxo-1,2,3,6-tetrahydropyridin-3-yl]phenyl}piperazin-1-yl)methyl]cyclohexyl}-4-({4-[(3S)-3-hydroxy-3-methylpiperidin-1-yl]-5-(trifluoromethyl)pyrimidin-2-yl}amino)-3-methylbenzene-1-sulfonamide | non-polymer | 845.4 | 1 | Chemie (A1B7G) | |||
| 6 | F (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
E: 96 - 378 (UniProt: P24864)
A: 1 - 1140 (UniProt: Q16531)
B: 40 - 442 (UniProt: Q96SW2)
| PDB | External Database | Details |
|---|---|---|
| Ser 93 | - | expression tag |
| Gly 94 | - | expression tag |
| Ser 95 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 1141 | - | expression tag |
| Ser 1142 | - | expression tag |
| His 1143 | - | expression tag |
| Pro 1144 | - | expression tag |
| Gln 1145 | - | expression tag |
| Phe 1146 | - | expression tag |
| Glu 1147 | - | expression tag |
| Lys 1148 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 38 | - | expression tag |
| Ser 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 241802.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 910.8 | |
| All* | Total formula weight | 242712.8 |
