9NXF

Crystal structure of CN:Tak1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Protein phosphatase 3 catalytic subunit alpha	polymer	370	42615.8	2	UniProt (Q08209) Pfam (PF00149)	Homo sapiens (human)	CAM-PRP catalytic subunit,Calcineurin A alpha,Calmodulin-dependent calcineurin A subunit alpha isoform,CNA alpha,Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
2	B, E (B, E)	Calcineurin subunit B type 1	polymer	156	17755.2	2	UniProt (P63098) Pfam (PF13499)	Homo sapiens (human)	Protein phosphatase 2B regulatory subunit 1,Protein phosphatase 3 regulatory subunit B alpha isoform 1
3	C, F (C, F)	IkB-like protein,Mitogen-activated protein kinase kinase kinase 7	polymer	53	6271.2	2	UniProt (O36972) UniProt (O43318)	Homo sapiens (human)	Ankyrin repeat domain-containing protein A238L,p28,Transforming growth factor-beta-activated kinase 1,TGF-beta-activated kinase 1
4	G, N (A, D)	FE (III) ION	non-polymer		55.8	2	Chemie (FE)
5	H, M, P (A, B, D)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
6	I, J, K, L, Q... (B, E)	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)
7	O (D)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
8	U, V, W, X, Y (A, B, D, E, F)	water	water		18.0	21	Chemie (HOH)

Sequence modifications

A, D: 1 - 370 (UniProt: Q08209)

PDB	External Database	Details
Ala 90	Asp 90	engineered mutation

B, E: 15 - 169 (UniProt: P63098)

PDB	External Database	Details
Met 14	-	expression tag

C, F: 393 - 421 (UniProt: O36972)

C, F: 422 - 442 (UniProt: O43318)

PDB	External Database	Details
Arg 441	Gln 441	engineered mutation
Pro 442	Asp 442	engineered mutation

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.