9NTT
Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 T-cell engager for the treatment of GPC3+ solid tumors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glypican-3 | polymer | 355 | 40475.0 | 1 | UniProt (P51654) | Homo sapiens (human) | GTR2-2,Intestinal protein OCI-5,MXR7 |
| 2 | B (B) | A0226018C08 | polymer | 127 | 13820.5 | 1 | Lama glama | ||
| 3 | C, D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 38 - 477 (UniProt: P51654)
| PDB | External Database | Details |
|---|---|---|
| Cys 35 | - | expression tag |
| His 36 | - | expression tag |
| Gln 37 | - | expression tag |
| Arg 39 | Pro 58 | conflict |
| - | Leu 187 | deletion |
| - | Pro 188 | deletion |
| - | Asp 189 | deletion |
| - | Ser 190 | deletion |
| - | Ala 191 | deletion |
| - | Asn 210 | deletion |
| - | Arg 227 | deletion |
| - | Ile 240 | deletion |
| - | Phe 248 | deletion |
| - | Tyr 311 | deletion |
| - | Arg 312 | deletion |
| - | Ile 313 | deletion |
| - | Tyr 314 | deletion |
| - | Ala 350 | deletion |
| - | His 351 | deletion |
| - | Ser 352 | deletion |
| - | Gln 353 | deletion |
| - | Gln 354 | deletion |
| - | Arg 355 | deletion |
| - | Gln 356 | deletion |
| - | Tyr 357 | deletion |
| - | Arg 358 | deletion |
| - | Ser 359 | deletion |
| - | Ala 360 | deletion |
| - | Tyr 361 | deletion |
| - | Tyr 362 | deletion |
| - | Pro 363 | deletion |
| - | Glu 364 | deletion |
| - | Asp 365 | deletion |
| - | Leu 366 | deletion |
| - | Phe 367 | deletion |
| - | Ile 368 | deletion |
| - | Asp 369 | deletion |
| - | Lys 370 | deletion |
| - | Lys 371 | deletion |
| - | Val 372 | deletion |
| - | Leu 373 | deletion |
| - | Lys 374 | deletion |
| - | Val 375 | deletion |
| - | Ala 376 | deletion |
| - | His 377 | deletion |
| - | Val 378 | deletion |
| - | Glu 379 | deletion |
| - | His 380 | deletion |
| - | Glu 381 | deletion |
| - | Glu 382 | deletion |
| - | Lys 435 | deletion |
| - | Ala 436 | deletion |
| - | Ala 437 | deletion |
| - | Arg 438 | deletion |
| - | Asn 439 | deletion |
| - | Gly 440 | deletion |
| - | Met 441 | deletion |
| - | Lys 442 | deletion |
| - | Asn 443 | deletion |
| - | Gln 444 | deletion |
| - | Phe 445 | deletion |
| - | Asn 446 | deletion |
| - | Leu 447 | deletion |
| - | His 448 | deletion |
| - | Glu 449 | deletion |
| - | Leu 450 | deletion |
| - | Lys 451 | deletion |
| - | Met 452 | deletion |
| - | Lys 453 | deletion |
| - | Gly 454 | deletion |
| - | Pro 455 | deletion |
| - | Glu 456 | deletion |
| - | Lys 467 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54295.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 54737.9 |
