9NRC
TMPRSS6 in complex with REGN7999 Fab and REGN8023 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transmembrane protease serine 6 | polymer | 763 | 85154.8 | 1 | UniProt (Q8IU80) Pfam (PF01390) Pfam (PF00057) Pfam (PF00089) | Homo sapiens (human) | Matriptase-2 |
| 2 | B (L) | REGN7999 Fab light chain | polymer | 214 | 23381.9 | 1 | Homo sapiens | ||
| 3 | C (H) | REGN7999 Fab heavy chain | polymer | 240 | 25604.5 | 1 | Homo sapiens | ||
| 4 | D (B) | REGN8023 Fab light chain | polymer | 220 | 24117.9 | 1 | Homo sapiens | ||
| 5 | E (C) | REGN8023 Fab heavy chain | polymer | 237 | 25308.6 | 1 | Homo sapiens | ||
| 6 | F, G, H (E, D, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 7 | I, M, N (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 8 | J, K, L (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) |
Sequence modifications
A: 77 - 811 (UniProt: Q8IU80)
| PDB | External Database | Details |
|---|---|---|
| Ala 762 | Ser 762 | engineered mutation |
| Glu 812 | - | expression tag |
| Gln 813 | - | expression tag |
| Lys 814 | - | expression tag |
| Leu 815 | - | expression tag |
| Ile 816 | - | expression tag |
| Ser 817 | - | expression tag |
| Glu 818 | - | expression tag |
| Glu 819 | - | expression tag |
| Asp 820 | - | expression tag |
| Leu 821 | - | expression tag |
| Gly 822 | - | expression tag |
| Gly 823 | - | expression tag |
| Glu 824 | - | expression tag |
| Gln 825 | - | expression tag |
| Lys 826 | - | expression tag |
| Leu 827 | - | expression tag |
| Ile 828 | - | expression tag |
| Ser 829 | - | expression tag |
| Glu 830 | - | expression tag |
| Glu 831 | - | expression tag |
| Asp 832 | - | expression tag |
| Leu 833 | - | expression tag |
| His 834 | - | expression tag |
| His 835 | - | expression tag |
| His 836 | - | expression tag |
| His 837 | - | expression tag |
| His 838 | - | expression tag |
| His 839 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 183567.7 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 783.9 | |
| All* | Total formula weight | 185624.7 |
