9NQX
Human Neu2 Sialidase Engineered for Better Half-Life
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Sialidase-2 | polymer | 374 | 41908.0 | 3 | UniProt (Q9Y3R4) Pfam (PF13088) | Homo sapiens (human) | Cytosolic sialidase,N-acetyl-alpha-neuraminidase 2 |
| 2 | D, F, H (A, B, C) | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID | non-polymer | 291.3 | 3 | Chemie (DAN) PubChem (65309) | |||
| 3 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 4 | G, I (B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | J, K, L (A, B, C) | water | water | 18.0 | 399 | Chemie (HOH) |
Sequence modifications
A, B, C: 4 - 377 (UniProt: Q9Y3R4)
| PDB | External Database | Details |
|---|---|---|
| Tyr 6 | Val 6 | conflict |
| Arg 42 | Ala 42 | conflict |
| Gly 62 | Pro 62 | conflict |
| Glu 93 | Ala 93 | conflict |
| Tyr 126 | Gln 126 | conflict |
| Lys 187 | Ile 187 | conflict |
| Phe 242 | Ala 242 | conflict |
| Thr 270 | Gln 270 | conflict |
| Ala 332 | Cys 332 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 125723.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1033.4 | |
| All* | Total formula weight | 126757.3 |
