9NPR

RAVV glycoprotein in complex with hNPC1-C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (G, H, I)	NPC intracellular cholesterol transporter 1	polymer	280	31792.5	3	UniProt (O15118) Pfam (PF22314)	Homo sapiens (human)	Niemann-Pick C1 protein
2	D, F, H (A, B, C)	Envelope glycoprotein RAVV GP1	polymer	256	28417.1	3	UniProt (Q1PDC7)	Ravn virus - Ravn Kenya 1987	GP1,2,GP,Virion spike glycoprotein
3	E, G, I (D, E, F)	Envelope glycoprotein RAVV GP2	polymer	247	28195.5	3	UniProt (Q1PDC7)	Ravn virus - Ravn Kenya 1987	GP1,2,GP,Virion spike glycoprotein
4	J, K, L, P, Q... (K, L, M, Q, R...)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	6	In PDB GlyTouCan (G22768VO)
5	M, N, O (N, O, P)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)

Sequence modifications

G, H, I: 374 - 620 (UniProt: O15118)

PDB	External Database	Details
Met 351	-	expression tag
Asp 352	-	expression tag
Ala 353	-	expression tag
Met 354	-	expression tag
Lys 355	-	expression tag
Arg 356	-	expression tag
Gly 357	-	expression tag
Leu 358	-	expression tag
Cys 359	-	expression tag
Cys 360	-	expression tag
Val 361	-	expression tag
Leu 362	-	expression tag
Leu 363	-	expression tag
Leu 364	-	expression tag
Cys 365	-	expression tag
Gly 366	-	expression tag
Ala 367	-	expression tag
Val 368	-	expression tag
Phe 369	-	expression tag
Val 370	-	expression tag
Ser 371	-	expression tag
Ala 372	-	expression tag
Ser 373	-	expression tag
Gly 621	-	expression tag
Ser 622	-	expression tag
Trp 623	-	expression tag
Ser 624	-	expression tag
His 625	-	expression tag
Pro 626	-	expression tag
Gln 627	-	expression tag
Phe 628	-	expression tag
Glu 629	-	expression tag
Lys 630	-	expression tag

D, E, F: 426 - 637 (UniProt: Q1PDC7)

PDB	External Database	Details
Ile 589	His 589	conflict
Ser 638	-	expression tag
Gly 639	-	expression tag
Tyr 640	-	expression tag
Ile 641	-	expression tag
Pro 642	-	expression tag
Glu 643	-	expression tag
Ala 644	-	expression tag
Pro 645	-	expression tag
Arg 646	-	expression tag
Asp 647	-	expression tag
Gly 648	-	expression tag
Gln 649	-	expression tag
Ala 650	-	expression tag
Tyr 651	-	expression tag
Val 652	-	expression tag
Arg 653	-	expression tag
Lys 654	-	expression tag
Asp 655	-	expression tag
Gly 656	-	expression tag
Glu 657	-	expression tag
Trp 658	-	expression tag
Val 659	-	expression tag
Leu 660	-	expression tag
Leu 661	-	expression tag
Ser 662	-	expression tag
Thr 663	-	expression tag
Phe 664	-	expression tag
Leu 665	-	expression tag
Gly 666	-	expression tag
His 667	-	expression tag
His 668	-	expression tag
His 669	-	expression tag
His 670	-	expression tag
His 671	-	expression tag
His 672	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	265215.3
Branched	Number of molecules	9
	Total formula weight	7224.6
All*	Total formula weight	272439.8

*Water molecules are not included.