9NIN

The structure of human Vacuolar Protein Sorting 34 catalytic domain bound to RD-I-86

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phosphatidylinositol 3-kinase catalytic subunit type 3	polymer	594	68149.9	1	UniProt (Q8NEB9) Pfam (PF00613) Pfam (PF00454)	Homo sapiens (human)	PI3-kinase type 3,PI3K type 3,PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34
2	B (A)	2-[(8R)-pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-benzothiazol-6-ol	non-polymer		268.3	1	Chemie (A1BYW)
3	C, G (A)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4	D, E, F, I (A)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
5	H (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
6	J, K, L, M, N... (A)	CHLORIDE ION	non-polymer		35.5	14	Chemie (CL)
7	X (A)	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
8	Y (A)	water	water		18.0	281	Chemie (HOH)

Sequence modifications

A: 290 - 871 (UniProt: Q8NEB9)

PDB	External Database	Details
Met 278	-	expression tag
Gly 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
His 286	-	expression tag
His 287	-	expression tag
His 288	-	expression tag
His 289	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	68149.9
Non-Polymers*	Number of molecules	23
	Total formula weight	1276.2
All*	Total formula weight	69426.1

*Water molecules are not included.