9NIH

Crystal structure of HLA-DR4 presenting citrullinated Tenascin C peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class II histocompatibility antigen, DR alpha chain	polymer	189	21919.6	1	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	MHC class II antigen DRA
2	B (B)	HLA class II histocompatibility antigen DR beta chain	polymer	198	23080.5	1	UniProt (A0A1V1IGJ9) Pfam (PF00969) Pfam (PF07654)	Homo sapiens (human)	MHC class II antigen
3	C (C)	Tenascin	polymer	14	1714.9	1	UniProt (P24821)	Homo sapiens	TN,Cytotactin,GMEM,GP 150-225,Glioma-associated-extracellular matrix antigen,Hexabrachion,JI,Myotendinous antigen,Neuronectin,Tenascin-C,TN-C
4	D, F (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	E, G, H (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6	I, J, K (A, B, C)	water	water		18.0	110	Chemie (HOH)

Sequence modifications

A: 5 - 181 (UniProt: P01903)

PDB	External Database	Details
Ile 1	-	expression tag
Lys 2	-	expression tag
Glu 3	-	expression tag
Glu 4	-	expression tag
Thr 182	-	expression tag
Ser 183	-	expression tag
Gly 184	-	expression tag
Asp 185	-	expression tag
Asp 186	-	expression tag
Asp 187	-	expression tag
Asp 188	-	expression tag
Lys 189	-	expression tag

B: 1 - 190 (UniProt: A0A1V1IGJ9)

PDB	External Database	Details
Thr 191	-	expression tag
Gly 192	-	expression tag
Gly 193	-	expression tag
Asp 194	-	expression tag
Asp 195	-	expression tag
Asp 196	-	expression tag
Asp 197	-	expression tag
Lys 198	-	expression tag

C: 1013 - 1024 (UniProt: P24821)

PDB	External Database	Details
Lys 1025	-	insertion
Lys 1026	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	46715.0
Non-Polymers*	Number of molecules	5
	Total formula weight	718.7
All*	Total formula weight	47433.7

*Water molecules are not included.