9NE8
Human polymerase epsilon bound to PCNA and DNA with an in-situ-generated mismatch in the mismatch-locking state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase epsilon catalytic subunit A | polymer | 1200 | 138137.6 | 1 | UniProt (Q07864) Pfam (PF03104) Pfam (PF22634) | Homo sapiens (human) | 3'-5' exodeoxyribonuclease,DNA polymerase II subunit A |
| 2 | B, C, D (B, C, D) | Proliferating cell nuclear antigen | polymer | 261 | 28795.8 | 3 | UniProt (P12004) Pfam (PF00705) Pfam (PF02747) | Homo sapiens (human) | PCNA,Cyclin |
| 3 | E (P) | DNA (33-MER) | polymer | 33 | 10236.6 | 1 | synthetic construct | ||
| 4 | F (T) | DNA (47-MER) | polymer | 47 | 14419.3 | 1 | synthetic construct | ||
| 5 | G (A) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) |
Sequence modifications
A: 1 - 1200 (UniProt: Q07864)
| PDB | External Database | Details |
|---|---|---|
| Ala 275 | Asp 275 | conflict |
| Ala 277 | Glu 277 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 249180.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 351.6 | |
| All* | Total formula weight | 249532.4 |
