9NDP
Structure of stalled ribosome and nascent chain in complex with NMT2 and NAC
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | Ribosomal protein S27a | polymer | 156 | 18004.0 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) | Oryctolagus cuniculus (rabbit) | |
| 2 | B (4) | mRNA | polymer | 6 | 1877.2 | 1 | Homo sapiens | ||
| 3 | C (6) | RACK1 | polymer | 317 | 35115.7 | 1 | UniProt (G1SJB4) Pfam (PF00400) | Oryctolagus cuniculus (rabbit) | |
| 4 | D (7) | 5S rRNA | polymer | 120 | 38691.9 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 5 | E (9) | eS29 | polymer | 56 | 6690.8 | 1 | UniProt (G1U7M4) Pfam (PF00253) | Oryctolagus cuniculus (rabbit) | |
| 6 | F (A) | Ribosomal protein L8 | polymer | 257 | 28088.9 | 1 | UniProt (G1TT27) Pfam (PF03947) Pfam (PF00181) | Oryctolagus cuniculus (rabbit) | |
| 7 | G (B) | Ribosomal protein L3 | polymer | 403 | 46108.0 | 1 | UniProt (G1TL06) Pfam (PF00297) | Oryctolagus cuniculus (rabbit) | |
| 8 | H (C) | 60S ribosomal protein L4 | polymer | 413 | 46388.9 | 1 | UniProt (G1SVW5) Pfam (PF00573) Pfam (PF14374) | Oryctolagus cuniculus (rabbit) | |
| 9 | I (D) | Large ribosomal subunit protein uL18 | polymer | 297 | 34481.8 | 1 | UniProt (P19949) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L5 |
| 10 | J (F) | Large ribosomal subunit protein uL30 | polymer | 249 | 29514.3 | 1 | UniProt (A0AAG1W3S3) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L7 |
| 11 | K (G) | 60S ribosomal protein L7a | polymer | 319 | 36221.5 | 1 | UniProt (G1STW0) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | |
| 12 | L (H) | 60S ribosomal protein L9 | polymer | 192 | 21871.4 | 1 | UniProt (G1SWI6) Pfam (PF00347) | Oryctolagus cuniculus (rabbit) | |
| 13 | M (I) | 60S ribosomal protein L10 | polymer | 214 | 24643.1 | 1 | UniProt (B7NZQ2) Pfam (PF00252) | Oryctolagus cuniculus (rabbit) | Ribosomal protein L10 (Predicted) |
| 14 | N (J) | Ribosomal protein L11 | polymer | 178 | 20288.5 | 1 | UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673) | Oryctolagus cuniculus (rabbit) | |
| 15 | O (K) | 18S rRNA | polymer | 1698 | 548040.2 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 16 | P (L) | eL13 | polymer | 211 | 24331.7 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 17 | Q (M) | 60S ribosomal protein L14 | polymer | 218 | 23870.5 | 1 | UniProt (G1SZ12) Pfam (PF01929) | Oryctolagus cuniculus (rabbit) | |
| 18 | R (N) | Ribosomal protein L15 | polymer | 204 | 24207.3 | 1 | UniProt (G1T0C1) Pfam (PF00827) | Oryctolagus cuniculus (rabbit) | |
| 19 | S (O) | Large ribosomal subunit protein uL13 | polymer | 203 | 23533.3 | 1 | UniProt (G1TVS8) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L13a |
| 20 | T (P) | Large ribosomal subunit protein uL22 | polymer | 184 | 21444.2 | 1 | UniProt (G1SCJ6) Pfam (PF00237) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L17 |
| 21 | U (Q) | Ribosomal protein L18 | polymer | 188 | 21721.7 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 22 | V (R) | Ribosomal protein L19 | polymer | 181 | 21715.2 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 23 | W (S) | 60S ribosomal protein L18a | polymer | 176 | 20661.3 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 24 | X (T) | eL21 | polymer | 160 | 18610.0 | 1 | UniProt (G1SHQ2) Pfam (PF01157) | Oryctolagus cuniculus (rabbit) | |
| 25 | Y (U) | eL22 | polymer | 115 | 13322.0 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 26 | Z (V) | Ribosomal protein L23 | polymer | 140 | 14892.5 | 1 | UniProt (G1T6D1) Pfam (PF00238) | Oryctolagus cuniculus (rabbit) | |
| 27 | AA (W) | eL24 | polymer | 157 | 17825.1 | 1 | UniProt (G1SE28) Pfam (PF01246) | Oryctolagus cuniculus (rabbit) | |
| 28 | BA (X) | eL23 | polymer | 156 | 17768.2 | 1 | UniProt (G1SE76) Pfam (PF03939) Pfam (PF00276) | Oryctolagus cuniculus (rabbit) | |
| 29 | CA (Y) | uL24 | polymer | 145 | 17303.4 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) | Oryctolagus cuniculus (rabbit) | |
| 30 | DA (Z) | 60S ribosomal protein L27 | polymer | 136 | 15835.8 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) | Oryctolagus cuniculus (rabbit) | |
| 31 | EA (a) | 60S ribosomal protein L27a | polymer | 148 | 16620.6 | 1 | UniProt (G1SNY0) Pfam (PF00828) | Oryctolagus cuniculus (rabbit) | |
| 32 | FA (c) | eL30 | polymer | 115 | 12807.1 | 1 | UniProt (G1TDL2) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | |
| 33 | GA (d) | eL31 | polymer | 125 | 14494.9 | 1 | UniProt (G1SHG0) Pfam (PF01198) | Oryctolagus cuniculus (rabbit) | |
| 34 | HA (e) | 60S ribosomal protein L32 | polymer | 134 | 15767.7 | 1 | UniProt (A0AAG1WVT3) | Oryctolagus cuniculus (rabbit) | |
| 35 | IA (f) | eL33 | polymer | 110 | 12580.8 | 1 | UniProt (G1SF08) Pfam (PF01247) | Oryctolagus cuniculus (rabbit) | |
| 36 | JA (g) | 60S ribosomal protein L34 | polymer | 117 | 13326.1 | 1 | UniProt (G1TXG5) Pfam (PF01199) | Oryctolagus cuniculus (rabbit) | |
| 37 | KA (h) | eL35 | polymer | 123 | 14566.6 | 1 | UniProt (G1SIT5) Pfam (PF00831) | Oryctolagus cuniculus (rabbit) | |
| 38 | LA (i) | 60S ribosomal protein L36 | polymer | 105 | 12263.8 | 1 | UniProt (G1TTQ5) Pfam (PF01158) | Oryctolagus cuniculus (rabbit) | |
| 39 | MA (j) | Ribosomal protein L37 | polymer | 97 | 11111.0 | 1 | UniProt (U3KPD5) Pfam (PF01907) | Oryctolagus cuniculus (rabbit) | |
| 40 | NA (k) | Large ribosomal subunit protein eL38 | polymer | 107 | 12047.5 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 41 | OA (l) | eL39 | polymer | 51 | 6455.8 | 1 | UniProt (G1TTN1) Pfam (PF00832) | Oryctolagus cuniculus (rabbit) | |
| 42 | PA (m) | Ubiquitin-ribosomal protein eL40 fusion protein | polymer | 128 | 14758.4 | 1 | UniProt (P0DXC2) | Oryctolagus cuniculus (rabbit) | Ubiquitin A-52 residue ribosomal protein fusion product 1 |
| 43 | QA (n) | eL41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (rabbit) | 60s ribosomal protein l41 |
| 44 | RA (o) | Ribosomal protein L36a | polymer | 141 | 16130.2 | 1 | UniProt (A0A5F9D391) Pfam (PF00935) | Oryctolagus cuniculus (rabbit) | |
| 45 | SA (p) | eL43 | polymer | 92 | 10299.4 | 1 | UniProt (G1SY53) Pfam (PF01780) | Oryctolagus cuniculus (rabbit) | |
| 46 | TA (q) | uS2 (SA) | polymer | 295 | 32958.0 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 47 | UA (r) | eL28 | polymer | 137 | 15783.6 | 1 | UniProt (G1U7L1) Pfam (PF01778) | Oryctolagus cuniculus (rabbit) | |
| 48 | VA (u) | 40S ribosomal protein S3a | polymer | 264 | 30002.1 | 1 | UniProt (G1SS70) Pfam (PF01015) | Oryctolagus cuniculus (rabbit) | |
| 49 | WA (v) | Small ribosomal subunit protein uS5 | polymer | 255 | 27502.2 | 1 | UniProt (A0AAG1W6H3) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S2 |
| 50 | XA (w) | Ribosomal protein S3 | polymer | 243 | 26715.3 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) | Oryctolagus cuniculus (rabbit) | |
| 51 | YA (x) | eS4 | polymer | 263 | 29596.8 | 1 | UniProt (G1TK17) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S4 |
| 52 | ZA (z) | 40S ribosomal protein S6 | polymer | 249 | 28751.9 | 1 | UniProt (G1TM55) Pfam (PF01092) | Oryctolagus cuniculus (rabbit) | |
| 53 | AB (s) | 60S acidic ribosomal protein P0 | polymer | 318 | 34380.5 | 1 | UniProt (G1SPK4) Pfam (PF00466) Pfam (PF17777) Pfam (PF00428) | Oryctolagus cuniculus (rabbit) | |
| 54 | BB (t) | 60S ribosomal protein L12 | polymer | 165 | 17847.6 | 1 | UniProt (G1SMR7) Pfam (PF03946) Pfam (PF00298) | Oryctolagus cuniculus (rabbit) | |
| 55 | CB (2) | tRNA | polymer | 76 | 24414.5 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 56 | DB (5) | 28S rRNA | polymer | 3534 | 1145287.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 57 | EB (8) | 5.8S rRNA | polymer | 151 | 48545.7 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 58 | FB (E) | 60S ribosomal protein L6 | polymer | 291 | 33028.3 | 1 | UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159) | Oryctolagus cuniculus (rabbit) | |
| 59 | GB (b) | Large ribosomal subunit protein eL29 | polymer | 245 | 26708.7 | 1 | UniProt (G1SGR6) Pfam (PF01779) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L29 |
| 60 | HB (y) | Ribosomal protein S5 | polymer | 204 | 22913.5 | 1 | UniProt (G1TFM5) Pfam (PF00177) | Oryctolagus cuniculus (rabbit) | |
| 61 | IB (BB) | 40S ribosomal protein S7 | polymer | 194 | 22168.9 | 1 | UniProt (G1SVB0) | Oryctolagus cuniculus (rabbit) | |
| 62 | JB (CC) | 40S ribosomal protein S8 | polymer | 208 | 24263.4 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 63 | KB (DD) | Ribosomal protein S9 (Predicted) | polymer | 194 | 22641.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) | Oryctolagus cuniculus (rabbit) | |
| 64 | LB (SS) | S10_plectin domain-containing protein | polymer | 165 | 18933.8 | 1 | UniProt (G1TPV3) Pfam (PF03501) | Oryctolagus cuniculus (rabbit) | |
| 65 | MB (EE) | Ribosomal protein S11 | polymer | 158 | 18468.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) | Oryctolagus cuniculus (rabbit) | |
| 66 | NB (RR) | 40S ribosomal protein S12 | polymer | 132 | 14539.0 | 1 | UniProt (G1SFR8) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | |
| 67 | OB (QQ) | Ribosomal protein S13 | polymer | 151 | 17259.4 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) | Oryctolagus cuniculus (rabbit) | |
| 68 | PB (MM) | Small ribosomal subunit protein uS11 | polymer | 151 | 16302.8 | 1 | UniProt (G1T1F0) Pfam (PF00411) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S14 |
| 69 | QB (WW) | uS19 | polymer | 145 | 17049.2 | 1 | UniProt (G1U0Q2) Pfam (PF00203) | Oryctolagus cuniculus (rabbit) | |
| 70 | RB (UU) | uS9 | polymer | 146 | 16477.4 | 1 | UniProt (G1SGX4) Pfam (PF00380) | Oryctolagus cuniculus (rabbit) | |
| 71 | SB (KK) | eS17 | polymer | 135 | 15552.1 | 1 | UniProt (G1TU13) Pfam (PF00833) | Oryctolagus cuniculus (rabbit) | |
| 72 | TB (II) | uS13 | polymer | 152 | 17759.8 | 1 | UniProt (G1TPG3) Pfam (PF00416) | Oryctolagus cuniculus (rabbit) | |
| 73 | UB (PP) | eS19 | polymer | 145 | 16106.6 | 1 | UniProt (G1TN62) Pfam (PF01090) | Oryctolagus cuniculus (rabbit) | |
| 74 | VB (GG) | uS10 | polymer | 119 | 13398.8 | 1 | UniProt (G1SIZ2) Pfam (PF00338) | Oryctolagus cuniculus (rabbit) | |
| 75 | WB (HH) | Small ribosomal subunit protein eS21 | polymer | 83 | 9074.3 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 76 | XB (TT) | Ribosomal protein S15a | polymer | 130 | 14865.6 | 1 | UniProt (G1TG89) Pfam (PF00410) | Oryctolagus cuniculus (rabbit) | |
| 77 | YB (VV) | uS12 | polymer | 143 | 15844.7 | 1 | UniProt (G1SZ47) Pfam (PF00164) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S23 |
| 78 | ZB (NN) | Small ribosomal subunit protein eS24 | polymer | 133 | 15463.3 | 1 | UniProt (A0A5F9D2E6) Pfam (PF01282) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S24 |
| 79 | AC (OO) | eS25 | polymer | 124 | 13645.0 | 1 | UniProt (G1TDB3) Pfam (PF03297) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S25 |
| 80 | BC (LL) | Small ribosomal subunit protein eS26 | polymer | 117 | 13147.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 81 | CC (JJ) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (G1TZ76) Pfam (PF01667) | Oryctolagus cuniculus (rabbit) | |
| 82 | DC (FF) | Ribosomal protein S28 | polymer | 69 | 7855.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) | Oryctolagus cuniculus (rabbit) | |
| 83 | EC (AA) | 40S ribosomal protein S30 | polymer | 133 | 14498.9 | 1 | UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758) | Oryctolagus cuniculus (rabbit) | |
| 84 | FC (EF) | Isoform 2 of Transcription factor BTF3 | polymer | 162 | 17724.0 | 1 | UniProt (P20290) Pfam (PF01849) | Homo sapiens (human) | Nascent polypeptide-associated complex subunit beta,NAC-beta,RNA polymerase B transcription factor 3 |
| 85 | GC (EG) | Nascent polypeptide-associated complex subunit alpha | polymer | 215 | 23406.8 | 1 | UniProt (Q13765) Pfam (PF01849) Pfam (PF19026) | Homo sapiens (human) | NAC-alpha,Alpha-NAC |
| 86 | HC (NA) | Glycylpeptide N-tetradecanoyltransferase 2 | polymer | 498 | 57061.1 | 1 | UniProt (O60551) Pfam (PF01233) Pfam (PF02799) | Homo sapiens (human) | Myristoyl-CoA:protein N-myristoyltransferase 2,NMT 2,Peptide N-myristoyltransferase 2,Protein-lysine myristoyltransferase NMT2,Type II N-myristoyltransferase |
| 87 | IC (NB) | Myristoylated alanine-rich C-kinase substrate,X-box-binding protein 1, luminal form | polymer | 74 | 7682.5 | 1 | UniProt (P30009) UniProt (P17861) | Homo sapiens (human) | MARCKS,Protein kinase C substrate 80 kDa protein |
| 88 | AD, AE, AF, AH, AI... (K, 5, 7, A, I...) | MAGNESIUM ION | non-polymer | 24.3 | 296 | Chemie (MG) | |||
| 89 | AG, VF, XF, YF, YN... (p, g, j, m, LL...) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 90 | ZN (NA) | COENZYME A | non-polymer | 767.5 | 1 | Chemie (COA) |
Sequence modifications
G: 1 - 319 (UniProt: G1STW0)
v: 39 - 293 (UniProt: A0AAG1W6H3)
x: 1 - 263 (UniProt: G1TK17)
PP: 1 - 145 (UniProt: G1TN62)
NB: 2 - 51 (UniProt: P30009)
NB: null - 75 (UniProt: P17861)
| PDB | External Database | Details |
|---|---|---|
| Gly 244 | Cys 244 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 57 | Asp 19 | conflict |
| Phe 97 | Cys 59 | conflict |
| Val 141 | Leu 103 | conflict |
| Pro 181 | Leu 143 | conflict |
| Val 191 | - | insertion |
| Met 215 | Leu 176 | conflict |
| Asp 271 | Asn 232 | conflict |
| Val 274 | Met 235 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | Ser 25 | conflict |
| Val 156 | Met 156 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | Trp 119 | conflict |
NB: null - 75 (UniProt: P17861)
| PDB | External Database | Details |
|---|---|---|
| Cys 69 | Pro 254 | conflict |
| Ala 70 | Ser 255 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 87 |
| Total formula weight | 3434878.7 | |
| Non-Polymers* | Number of molecules | 303 |
| Total formula weight | 8354.3 | |
| All* | Total formula weight | 3443232.9 |
