9NB6
Cryo-EM structure of the CD163/Hp(1-1)Hb complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Scavenger receptor cysteine-rich type 1 protein M130 | polymer | 1012 | 109731.6 | 3 | UniProt (Q86VB7) Pfam (PF00530) | Homo sapiens (human) | Hemoglobin scavenger receptor |
| 2 | D (D) | Hemoglobin subunit alpha | polymer | 142 | 15281.5 | 1 | UniProt (P69905) Pfam (PF00042) | Homo sapiens (human) | Alpha-globin,Hemoglobin alpha chain |
| 3 | E (E) | Hemoglobin subunit beta | polymer | 147 | 16021.4 | 1 | UniProt (P68871) Pfam (PF00042) | Homo sapiens (human) | Beta-globin,Hemoglobin beta chain |
| 4 | F, G (F, G) | Isoform 2 of Haptoglobin | polymer | 347 | 38497.7 | 2 | UniProt (P00738) Pfam (PF00089) | Homo sapiens (human) | Zonulin |
| 5 | EA, FA, GA, H, I... (C, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
| 6 | AA, BA, CA, DA, HA... (B, C, A) | CALCIUM ION | non-polymer | 40.1 | 23 | Chemie (CA) | |||
| 7 | NA, PA (D, E) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 8 | OA, QA (D, E) | OXYGEN MOLECULE | non-polymer | 32.0 | 2 | Chemie (OXY) |
Sequence modifications
A, B, C: 42 - 1045 (UniProt: Q86VB7)
| PDB | External Database | Details |
|---|---|---|
| His 1046 | - | expression tag |
| His 1047 | - | expression tag |
| His 1048 | - | expression tag |
| His 1049 | - | expression tag |
| His 1050 | - | expression tag |
| His 1051 | - | expression tag |
| His 1052 | - | expression tag |
| His 1053 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 437492.9 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 4209.6 | |
| All* | Total formula weight | 441702.6 |
