9NA3

IRAK4 in Complex with Compound 15

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, H0A0)	Interleukin-1 receptor-associated kinase 4	polymer	304	34215.5	2	UniProt (Q9NWZ3) Pfam (PF07714)	Homo sapiens (human)	IRAK-4,Renal carcinoma antigen NY-REN-64
2	C, D (A, H0A0)	(6P)-6-[(8R)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-N-[(2S)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(4-hydroxybicyclo[2.2.2]octan-1-yl)amino]pyridine-3-carboxamide	non-polymer		506.6	2	Chemie (A1BWX)
3	E, F (A, H0A0)	water	water		18.0	120	Chemie (HOH)

Sequence modifications

A, H0A0: 160 - 460 (UniProt: Q9NWZ3)

PDB	External Database	Details
Gly 157	-	expression tag
Ala 158	-	expression tag
Met 159	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68431.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1013.1
All*	Total formula weight	69444.2

*Water molecules are not included.