9N9Y

Crystal structure of truncated USP1:UAF1 in complex with compound 18

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	WD repeat-containing protein 48	polymer	569	64019.4	1	UniProt (Q8TAF3) Pfam (PF00400) Pfam (PF11816)	Homo sapiens (human)	USP1-associated factor 1,WD repeat endosomal protein,p80
2	B (B)	Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment,Ubiquitin carboxyl-terminal hydrolase 1	polymer	381	42954.5	1	UniProt (O94782) Pfam (PF00443)	Homo sapiens (human)	Deubiquitinating enzyme 1,hUBP,Ubiquitin thioesterase 1,Ubiquitin-specific-processing protease 1
3	C (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (B)	2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-7-({4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl}methyl)-5H-pyrrolo[3,2-d]pyrimidine	non-polymer		505.5	1	Chemie (A1BWW)
5	E, F (A, B)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A: 1 - 563 (UniProt: Q8TAF3)

PDB	External Database	Details
Glu 564	-	expression tag
Asn 565	-	expression tag
Leu 566	-	expression tag
Tyr 567	-	expression tag
Phe 568	-	expression tag
Gln 569	-	expression tag

B: 85 - 222 (UniProt: O94782)

PDB	External Database	Details
Gly 84	-	expression tag

B: 421 - 605 (UniProt: O94782)

PDB	External Database	Details
Gly 223	-	linker
Ser 224	-	linker
Gly 225	-	linker
Ser 414	-	linker
Gly 415	-	linker
Ser 416	-	linker
Gly 417	-	linker
Ser 418	-	linker
Gly 419	-	linker
Ser 420	-	linker

B: 739 - 785 (UniProt: O94782)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	106973.9
Non-Polymers*	Number of molecules	2
	Total formula weight	570.9
All*	Total formula weight	107544.8

*Water molecules are not included.