9N9W

Cryo-EM structure of AMPPNP bound human phosphoribosylformylglycinamidine synthase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phosphoribosylformylglycinamidine synthase	polymer	1369	148495.7	1	UniProt (O15067)	Homo sapiens (human)	FGAM synthase,FGAMS,Formylglycinamide ribonucleotide amidotransferase,FGAR amidotransferase,FGAR-AT,Formylglycinamide ribotide amidotransferase,Phosphoribosylformylglycineamide amidotransferase
2	B (A)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
3	C (A)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
4	D, E, F (A)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
5	G (A)	water	water		18.0	55	Chemie (HOH)

Sequence modifications

A: 1 - 1338 (UniProt: O15067)

PDB	External Database	Details
Thr 1339	-	expression tag
Arg 1340	-	expression tag
Thr 1341	-	expression tag
Arg 1342	-	expression tag
Pro 1343	-	expression tag
Leu 1344	-	expression tag
Glu 1345	-	expression tag
Gln 1346	-	expression tag
Lys 1347	-	expression tag
Leu 1348	-	expression tag
Ile 1349	-	expression tag
Ser 1350	-	expression tag
Glu 1351	-	expression tag
Glu 1352	-	expression tag
Asp 1353	-	expression tag
Leu 1354	-	expression tag
Ala 1355	-	expression tag
Ala 1356	-	expression tag
Asn 1357	-	expression tag
Asp 1358	-	expression tag
Ile 1359	-	expression tag
Leu 1360	-	expression tag
Asp 1361	-	expression tag
Tyr 1362	-	expression tag
Lys 1363	-	expression tag
Asp 1364	-	expression tag
Asp 1365	-	expression tag
Asp 1366	-	expression tag
Asp 1367	-	expression tag
Lys 1368	-	expression tag
Val 1369	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	148495.7
Non-Polymers*	Number of molecules	5
	Total formula weight	1006.3
All*	Total formula weight	149502.0

*Water molecules are not included.