9N9J
Structure of a GRP94 folding intermediate engaged with a CCDC134- and FKBP11-bound secretory translocon
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (5) | Translocon-associated protein subunit alpha | polymer | 286 | 32263.2 | 1 | UniProt (P43307) Pfam (PF03896) | Homo sapiens (human) | TRAP-alpha,Signal sequence receptor subunit alpha,SSR-alpha |
| 2 | B (6) | Translocon-associated protein subunit beta | polymer | 183 | 20155.0 | 1 | UniProt (P43308) Pfam (PF05753) | Homo sapiens (human) | TRAP-beta,Signal sequence receptor subunit beta,SSR-beta |
| 3 | C (7) | Translocon-associated protein subunit gamma | polymer | 185 | 21106.5 | 1 | UniProt (Q9UNL2) Pfam (PF07074) | Homo sapiens (human) | TRAP-gamma,Signal sequence receptor subunit gamma,SSR-gamma |
| 4 | D (8) | Translocon-associated protein subunit delta | polymer | 173 | 19015.5 | 1 | UniProt (P51571) Pfam (PF05404) | Homo sapiens (human) | TRAP-delta,Signal sequence receptor subunit delta,SSR-delta |
| 5 | E (A) | Peptidyl-prolyl cis-trans isomerase FKBP11 | polymer | 201 | 22213.4 | 1 | UniProt (Q9NYL4) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP11,19 kDa FK506-binding protein,19 kDa FKBP,FKBP-19,FK506-binding protein 11,FKBP-11,Rotamase |
| 6 | F (B) | Coiled-coil domain-containing protein 134 | polymer | 229 | 26598.6 | 1 | UniProt (Q9H6E4) Pfam (PF15002) | Homo sapiens (human) | |
| 7 | G (D) | Protein transport protein Sec61 subunit alpha isoform 1 | polymer | 476 | 52304.4 | 1 | UniProt (P61619) Pfam (PF10559) Pfam (PF00344) | Homo sapiens (human) | Sec61 alpha-1 |
| 8 | H (E) | Protein transport protein Sec61 subunit beta | polymer | 96 | 9987.5 | 1 | UniProt (P60468) Pfam (PF03911) | Homo sapiens (human) | |
| 9 | I (F) | Protein transport protein Sec61 subunit gamma | polymer | 68 | 7752.3 | 1 | UniProt (P60059) Pfam (PF00584) | Homo sapiens (human) | |
| 10 | J (G) | Stress-associated endoplasmic reticulum protein 1 | polymer | 66 | 7384.8 | 1 | UniProt (Q9Y6X1) Pfam (PF06624) | Homo sapiens (human) | Ribosome-attached membrane protein 4 |
| 11 | K (I) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A | polymer | 705 | 80607.3 | 1 | UniProt (P46977) Pfam (PF02516) Pfam (PF22627) | Homo sapiens (human) | Oligosaccharyl transferase subunit STT3A,STT3-A,B5,Integral membrane protein 1,Transmembrane protein TMC |
| 12 | L (J) | Oligosaccharyltransferase complex subunit OSTC | polymer | 149 | 16844.2 | 1 | UniProt (Q9NRP0) Pfam (PF04756) | Homo sapiens (human) | Hydrophobic protein HSF-28 |
| 13 | M (K2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 | polymer | 37 | 4196.0 | 1 | UniProt (P0C6T2) Pfam (PF10215) | Homo sapiens (human) | |
| 14 | N (L2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258 | polymer | 79 | 9083.8 | 1 | UniProt (P61165) Pfam (PF05251) | Homo sapiens (human) | Oligosaccharyl transferase subunit TMEM258,Transmembrane protein 258 |
| 15 | O (L5) | 28S ribosomal RNA | polymer | 5066 | 1638922.0 | 1 | Homo sapiens (human) | ||
| 16 | P (L7) | 5S ribosomal RNA | polymer | 121 | 38998.1 | 1 | GenBank (23898) | Homo sapiens (human) | |
| 17 | Q (L8) | 5.8S ribosomal RNA | polymer | 157 | 50449.8 | 1 | GenBank (555853) | Homo sapiens (human) | |
| 18 | R (LA) | 60S ribosomal protein L8 | polymer | 257 | 28088.9 | 1 | UniProt (P62917) Pfam (PF00181) Pfam (PF03947) | Homo sapiens (human) | Large ribosomal subunit protein uL2 |
| 19 | S (LB) | 60S ribosomal protein L3 | polymer | 403 | 46211.1 | 1 | UniProt (P39023) Pfam (PF00297) | Homo sapiens (human) | HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3 |
| 20 | T (LC) | Large ribosomal subunit protein uL4 | polymer | 427 | 47804.6 | 1 | UniProt (P36578) Pfam (PF00573) Pfam (PF14374) | Homo sapiens (human) | 60S ribosomal protein L4, 60S ribosomal protein L1 |
| 21 | U (LD) | Large ribosomal subunit protein uL18 | polymer | 297 | 34426.8 | 1 | UniProt (P46777) Pfam (PF17144) Pfam (PF14204) | Homo sapiens (human) | 60S ribosomal protein L5 |
| 22 | V (LE) | Large ribosomal subunit protein eL6 | polymer | 288 | 32810.2 | 1 | UniProt (Q02878) Pfam (PF03868) Pfam (PF01159) | Homo sapiens (human) | 60S ribosomal protein L6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107 |
| 23 | W (LF) | 60S ribosomal protein L7 | polymer | 248 | 29291.0 | 1 | UniProt (P18124) Pfam (PF08079) Pfam (PF00327) | Homo sapiens (human) | Large ribosomal subunit protein uL30 |
| 24 | X (LG) | Large ribosomal subunit protein eL8 | polymer | 266 | 30061.8 | 1 | UniProt (P62424) Pfam (PF01248) | Homo sapiens (human) | 60S ribosomal protein L7a,PLA-X polypeptide,Surfeit locus protein 3 |
| 25 | Y (LH) | Large ribosomal subunit protein uL6 | polymer | 192 | 21899.5 | 1 | UniProt (P32969) Pfam (PF00347) | Homo sapiens (human) | 60S ribosomal protein L9 |
| 26 | Z (LI) | Ribosomal protein uL16-like | polymer | 214 | 24570.9 | 1 | UniProt (Q96L21) Pfam (PF00252) | Homo sapiens (human) | 60S ribosomal protein L10-like,Large ribosomal subunit protein uL16-like |
| 27 | AA (LL) | Large ribosomal subunit protein eL13 | polymer | 211 | 24321.7 | 1 | UniProt (P26373) Pfam (PF01294) | Homo sapiens (human) | 60S ribosomal protein L13,Breast basic conserved protein 1 |
| 28 | BA (LM) | Large ribosomal subunit protein eL14 | polymer | 215 | 23485.0 | 1 | UniProt (P50914) Pfam (PF01929) | Homo sapiens (human) | 60S ribosomal protein L14,CAG-ISL 7 |
| 29 | CA (LN) | Large ribosomal subunit protein eL15 | polymer | 204 | 24207.3 | 1 | UniProt (P61313) Pfam (PF00827) | Homo sapiens (human) | 60S ribosomal protein L15 |
| 30 | DA (LO) | Large ribosomal subunit protein uL13 | polymer | 203 | 23633.4 | 1 | UniProt (P40429) Pfam (PF00572) | Homo sapiens (human) | 60S ribosomal protein L13a,23 kDa highly basic protein |
| 31 | EA (LP) | Large ribosomal subunit protein uL22 | polymer | 184 | 21443.2 | 1 | UniProt (P18621) Pfam (PF00237) | Homo sapiens (human) | 60S ribosomal protein L17,60S ribosomal protein L23,PD-1 |
| 32 | FA (LQ) | Large ribosomal subunit protein eL18 | polymer | 188 | 21687.7 | 1 | UniProt (Q07020) Pfam (PF17135) | Homo sapiens (human) | 60S ribosomal protein L18 |
| 33 | GA (LR) | Large ribosomal subunit protein eL19 | polymer | 196 | 23535.3 | 1 | UniProt (P84098) Pfam (PF01280) | Homo sapiens (human) | 60S ribosomal protein L19 |
| 34 | HA (LS) | Large ribosomal subunit protein eL20 | polymer | 176 | 20808.5 | 1 | UniProt (Q02543) Pfam (PF01775) | Homo sapiens (human) | 60S ribosomal protein L18a |
| 35 | IA (LT) | Large ribosomal subunit protein eL21 | polymer | 160 | 18610.0 | 1 | UniProt (P46778) Pfam (PF01157) | Homo sapiens (human) | 60S ribosomal protein L21 |
| 36 | JA (LU) | Large ribosomal subunit protein eL22 | polymer | 128 | 14813.0 | 1 | UniProt (P35268) Pfam (PF01776) | Homo sapiens (human) | 60S ribosomal protein L22,EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15 |
| 37 | KA (LV) | Large ribosomal subunit protein uL14 | polymer | 140 | 14892.5 | 1 | UniProt (P62829) Pfam (PF00238) | Homo sapiens (human) | 60S ribosomal protein L23,60S ribosomal protein L17 |
| 38 | LA (LW) | Large ribosomal subunit protein eL24 | polymer | 157 | 17825.1 | 1 | UniProt (P83731) Pfam (PF01246) | Homo sapiens (human) | 60S ribosomal protein L24,60S ribosomal protein L30 |
| 39 | MA (LX) | Large ribosomal subunit protein uL23 | polymer | 156 | 17740.2 | 1 | UniProt (P62750) Pfam (PF03939) Pfam (PF00276) | Homo sapiens (human) | 60S ribosomal protein L23a |
| 40 | NA (LY) | Large ribosomal subunit protein uL24 | polymer | 145 | 17303.4 | 1 | UniProt (P61254) Pfam (PF16906) Pfam (PF00467) | Homo sapiens (human) | 60S ribosomal protein L26 |
| 41 | OA (LZ) | Large ribosomal subunit protein eL27 | polymer | 136 | 15835.8 | 1 | UniProt (P61353) Pfam (PF00467) Pfam (PF01777) | Homo sapiens (human) | 60S ribosomal protein L27 |
| 42 | PA (La) | 60S ribosomal protein L27a | polymer | 148 | 16604.5 | 1 | UniProt (P46776) Pfam (PF00828) | Homo sapiens (human) | Large ribosomal subunit protein uL15 |
| 43 | QA (Lb) | 60S ribosomal protein L29 | polymer | 159 | 17804.3 | 1 | UniProt (P47914) Pfam (PF01779) | Homo sapiens (human) | Cell surface heparin-binding protein HIP,Large ribosomal subunit protein eL29 |
| 44 | RA (Lc) | Large ribosomal subunit protein eL30 | polymer | 115 | 12805.1 | 1 | UniProt (P62888) Pfam (PF01248) | Homo sapiens (human) | 60S ribosomal protein L30 |
| 45 | SA (Ld) | Large ribosomal subunit protein eL31 | polymer | 125 | 14494.9 | 1 | UniProt (P62899) Pfam (PF01198) | Homo sapiens (human) | 60S ribosomal protein L31 |
| 46 | TA (Le) | Large ribosomal subunit protein eL32 | polymer | 135 | 15898.9 | 1 | UniProt (P62910) Pfam (PF01655) | Homo sapiens (human) | 60S ribosomal protein L32 |
| 47 | UA (Lf) | Large ribosomal subunit protein eL33 | polymer | 110 | 12564.7 | 1 | UniProt (P18077) Pfam (PF01247) | Homo sapiens (human) | 60S ribosomal protein L35a,Cell growth-inhibiting gene 33 protein |
| 48 | VA (Lg) | Large ribosomal subunit protein eL34 | polymer | 117 | 13326.1 | 1 | UniProt (P49207) Pfam (PF01199) | Homo sapiens (human) | 60S ribosomal protein L34 |
| 49 | WA (Lh) | Large ribosomal subunit protein uL29 | polymer | 123 | 14593.6 | 1 | UniProt (P42766) Pfam (PF00831) | Homo sapiens (human) | 60S ribosomal protein L35 |
| 50 | XA (Li) | Large ribosomal subunit protein eL36 | polymer | 105 | 12290.9 | 1 | UniProt (Q9Y3U8) Pfam (PF01158) | Homo sapiens (human) | 60S ribosomal protein L36 |
| 51 | YA (Lj) | Large ribosomal subunit protein eL37 | polymer | 97 | 11111.0 | 1 | UniProt (P61927) Pfam (PF01907) | Homo sapiens (human) | 60S ribosomal protein L37,G1.16 |
| 52 | ZA (Lk) | Large ribosomal subunit protein eL38 | polymer | 70 | 8238.9 | 1 | UniProt (P63173) Pfam (PF01781) | Homo sapiens (human) | 60S ribosomal protein L38 |
| 53 | AB (Ll) | Large ribosomal subunit protein eL39 | polymer | 51 | 6426.8 | 1 | UniProt (P62891) Pfam (PF00832) | Homo sapiens (human) | 60S ribosomal protein L39 |
| 54 | BB (Lm) | Ubiquitin-60S ribosomal protein L40 | polymer | 128 | 14758.4 | 1 | UniProt (P62987) Pfam (PF00240) Pfam (PF01020) | Homo sapiens (human) | CEP52,Ubiquitin A-52 residue ribosomal protein fusion product 1 |
| 55 | CB (Ln) | Small ribosomal subunit protein eS32 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (human) | 60S ribosomal protein L41,HG12,Large ribosomal subunit protein eL41 |
| 56 | DB (Lo) | Large ribosomal subunit protein eL42 | polymer | 106 | 12477.0 | 1 | UniProt (P83881) Pfam (PF00935) | Homo sapiens (human) | 60S ribosomal protein L36a,60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein |
| 57 | EB (Lp) | Large ribosomal subunit protein eL43 | polymer | 92 | 10299.4 | 1 | UniProt (P61513) Pfam (PF01780) | Homo sapiens (human) | 60S ribosomal protein L37a |
| 58 | FB (Lr) | 60S ribosomal protein L28 | polymer | 137 | 15784.6 | 1 | UniProt (P46779) Pfam (PF01778) | Homo sapiens (human) | Large ribosomal subunit protein eL28 |
| 59 | GB (Ls) | 60S acidic ribosomal protein P0 | polymer | 317 | 34309.4 | 1 | UniProt (P05388) Pfam (PF00466) Pfam (PF17777) Pfam (PF00428) | Homo sapiens (human) | 60S ribosomal protein L10E,Large ribosomal subunit protein uL10 |
| 60 | HB (Lt) | 60S ribosomal protein L12 | polymer | 165 | 17847.6 | 1 | UniProt (P30050) Pfam (PF03946) Pfam (PF00298) | Homo sapiens (human) | Large ribosomal subunit protein uL11 |
| 61 | IB (Lz) | 60S ribosomal protein L10a | polymer | 217 | 24879.4 | 1 | UniProt (P62906) Pfam (PF00687) | Homo sapiens (human) | CSA-19,Large ribosomal subunit protein uL1,Neural precursor cell expressed developmentally down-regulated protein 6,NEDD-6 |
| 62 | JB (M2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 | polymer | 113 | 12503.6 | 1 | UniProt (P61803) Pfam (PF02109) | Homo sapiens (human) | Oligosaccharyl transferase subunit DAD1,Defender against cell death 1,DAD-1 |
| 63 | KB (N) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 | polymer | 136 | 14689.5 | 1 | UniProt (Q8N6L1) Pfam (PF09775) | Homo sapiens (human) | Oligosaccharyl transferase subunit KCP2,Keratinocyte-associated protein 2,KCP-2 |
| 64 | LB (N2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit | polymer | 456 | 50854.6 | 1 | UniProt (P39656) Pfam (PF03345) | Homo sapiens (human) | DDOST 48 kDa subunit,Oligosaccharyl transferase 48 kDa subunit |
| 65 | MB (O2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | polymer | 607 | 68656.2 | 1 | UniProt (P04843) Pfam (PF04597) | Homo sapiens (human) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit,Ribophorin I,RPN-I,Ribophorin-1 |
| 66 | NB (P2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 | polymer | 631 | 69347.5 | 1 | UniProt (P04844) Pfam (PF05817) | Homo sapiens (human) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit,RIBIIR,Ribophorin II,RPN-II,Ribophorin-2 |
| 67 | OB (u3) | tRNA | polymer | 76 | 24414.5 | 1 | Homo sapiens (human) | ||
| 68 | PB (v3) | tRNA | polymer | 76 | 24436.5 | 1 | Homo sapiens (human) | ||
| 69 | QB (y3) | Endoplasmin | polymer | 846 | 96254.2 | 1 | UniProt (P14625) Pfam (PF13589) Pfam (PF00183) | Homo sapiens (human) | 94 kDa glucose-regulated protein,GRP-94,Heat shock protein 90 kDa beta member 1,Heat shock protein family C member 4,Tumor rejection antigen 1,gp96 homolog |
| 70 | RB (LJ) | Large ribosomal subunit protein uL5 | polymer | 178 | 20288.5 | 1 | UniProt (P62913) Pfam (PF00281) Pfam (PF00673) | Homo sapiens (human) | 60S ribosomal protein L11, CLL-associated antigen KW-12 |
| 71 | SB (K) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 72 | TB (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 73 | UB (H) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G81980VO) | |||
| 74 | VB (L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G05026ZL) | |||
| 75 | WB (I) | phosphono [(3~{R},6~{E},10~{E})-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl] hydrogen phosphate | non-polymer | 452.5 | 1 | Chemie (ELU) | |||
| 76 | AC, AD, AE, AF, AG... (L5, L7, L8, LA, LI...) | MAGNESIUM ION | non-polymer | 24.3 | 226 | Chemie (MG) | |||
| 77 | OK, QK, RK, SK, TK (Lg, Lj, Lm, Lo, Lp) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 78 | UK (u3) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 70 |
| Total formula weight | 3324623.3 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3643.3 | |
| Non-Polymers* | Number of molecules | 232 |
| Total formula weight | 6272.4 | |
| All* | Total formula weight | 3334539.0 |
