9N8N
Tandem antigen chimera of Pfs230 and Pfs48/45 bound by potent mAbs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RUPA-39 heavy chain | polymer | 227 | 24054.0 | 1 | Homo sapiens | ||
| 2 | B (B) | RUPA-39 Kappa chain | polymer | 215 | 23420.9 | 1 | Homo sapiens | ||
| 3 | C (E) | RUPA-44 Kappa chain | polymer | 214 | 23483.1 | 1 | Homo sapiens | ||
| 4 | D (F) | RUPA-44 heavy chain | polymer | 230 | 24277.3 | 1 | Homo sapiens | ||
| 5 | E (I) | Gametocyte surface protein P230,Gametocyte surface protein P45/48 | polymer | 324 | 36568.2 | 1 | UniProt (P68874) UniProt (Q8I6T1) Pfam (PF07422) | Plasmodium falciparum 3D7 | |
| 6 | F (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 7 | BA, CA, DA, EA, G... (E, A, F, B, I) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 21 | Chemie (EDO) | |||
| 8 | J (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 9 | K, X, Y (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 10 | N, P, T, U (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) PubChem (8117) | |||
| 11 | S (B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) PubChem (3777159) | |||
| 12 | AA, FA, GA, IA, V (E, F, B) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) PubChem (175) | |||
| 13 | HA, W (E, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 14 | JA, LA (F) | CACODYLATE ION | non-polymer | 137.0 | 2 | Chemie (CAC) PubChem (167250) | |||
| 15 | TA, UA, VA, WA, XA (A, B, E, F, I) | water | water | 18.0 | 451 | Chemie (HOH) |
Sequence modifications
I: 1 - 173 (UniProt: P68874)
I: 182 - 315 (UniProt: Q8I6T1)
| PDB | External Database | Details |
|---|---|---|
| Gln 34 | Asn 585 | conflict |
| Val 174 | - | linker |
| Tyr 175 | - | linker |
| Val 176 | - | linker |
| Glu 177 | - | linker |
| Pro 178 | - | linker |
| Tyr 179 | - | linker |
| Gly 180 | - | linker |
| Lys 181 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gln 186 | Asn 299 | conflict |
| Tyr 195 | His 308 | conflict |
| Leu 284 | Gly 397 | conflict |
| Val 289 | Ile 402 | conflict |
| Gly 316 | - | expression tag |
| Thr 317 | - | expression tag |
| Lys 318 | - | expression tag |
| His 319 | - | expression tag |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
| His 323 | - | expression tag |
| His 324 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 131803.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 39 |
| Total formula weight | 2755.9 | |
| All* | Total formula weight | 135130.1 |
