9N67

Crystal structure of dihydroorotate dehydrogenase from Leishmania braziliensis in complex with orotate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dihydroorotate dehydrogenase	polymer	347	37401.8	2	UniProt (E9AI53)	Leishmania braziliensis
2	C, F (A, B)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	2	Chemie (FMN)
3	D, G (A, B)	OROTIC ACID	non-polymer		156.1	2	Chemie (ORO)
4	E, K, L, M (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
5	H, I, J (B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6	N, O (A, B)	water	water		18.0	564	Chemie (HOH)

Sequence modifications

A, B: 1 - 313 (UniProt: E9AI53)

PDB	External Database	Details
Met -33	-	initiating methionine
Gly -32	-	expression tag
Ser -31	-	expression tag
Ser -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
Ser -23	-	expression tag
Ser -22	-	expression tag
Gly -21	-	expression tag
Leu -20	-	expression tag
Val -19	-	expression tag
Pro -18	-	expression tag
Arg -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
Met -13	-	expression tag
Ala -12	-	expression tag
Ser -11	-	expression tag
Met -10	-	expression tag
Thr -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gln -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74803.6
Non-Polymers*	Number of molecules	11
	Total formula weight	1885.4
All*	Total formula weight	76689.0

*Water molecules are not included.