9N4K
CryoEM structure of ALK2-ActRIIB bound to BMP6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, F) | Activin receptor type-2B | polymer | 133 | 14933.4 | 2 | UniProt (Q13705) Pfam (PF01064) | Homo sapiens (human) | Activin receptor type IIB,ACTR-IIB |
| 2 | B, C (B, E) | Bone morphogenetic protein 6 | polymer | 139 | 15695.7 | 2 | UniProt (P22004) Pfam (PF00019) | Homo sapiens (human) | BMP-6,VG-1-related protein,VG-1-R,VGR-1 |
| 3 | E, F (C, D) | Activin receptor type-1 | polymer | 121 | 13189.9 | 2 | UniProt (Q04771) Pfam (PF01064) | Homo sapiens (human) | Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I |
| 4 | G, H (G, H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 5 | I, J, K, M, N... (A, B, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 6 | L, O (B, E) | beta-D-mannopyranose | non-polymer | 180.2 | 2 | Chemie (BMA) |
Sequence modifications
A, F: 19 - 134 (UniProt: Q13705)
C, D: 21 - 123 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Gly 135 | - | expression tag |
| Gly 136 | - | expression tag |
| Gly 137 | - | expression tag |
| Thr 138 | - | expression tag |
| His 139 | - | expression tag |
| Thr 140 | - | expression tag |
| Cys 141 | - | expression tag |
| Pro 142 | - | expression tag |
| Pro 143 | - | expression tag |
| Cys 144 | - | expression tag |
| Pro 145 | - | expression tag |
| Ala 146 | - | expression tag |
| Pro 147 | - | expression tag |
| Glu 148 | - | expression tag |
| Leu 149 | - | expression tag |
| Leu 150 | - | expression tag |
| Gly 151 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 124 | - | expression tag |
| Gly 125 | - | expression tag |
| Gly 126 | - | expression tag |
| Gly 127 | - | expression tag |
| Thr 128 | - | expression tag |
| His 129 | - | expression tag |
| Thr 130 | - | expression tag |
| Cys 131 | - | expression tag |
| Pro 132 | - | expression tag |
| Pro 133 | - | expression tag |
| Cys 134 | - | expression tag |
| Pro 135 | - | expression tag |
| Ala 136 | - | expression tag |
| Pro 137 | - | expression tag |
| Glu 138 | - | expression tag |
| Leu 139 | - | expression tag |
| Leu 140 | - | expression tag |
| Gly 141 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 87637.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1687.6 | |
| All* | Total formula weight | 90498.6 |
