9N3M
SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant bound to inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 3C-like proteinase | polymer | 306 | 33835.5 | 1 | UniProt (P0DTC1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO, 3CLp, Main protease, Mpro, Non-structural protein 5, nsp5, SARS coronavirus main proteinase |
| 2 | B (A) | (1S,2S,4S)-2-{[3-cyclopropyl-N-(4-methoxy-1H-indole-2-carbonyl)-L-alanyl]amino}-1-hydroxy-4-methyl-5-(methylamino)-5-oxopentane-1-sulfonic acid | non-polymer | 524.6 | 1 | Chemie (A1BVV) | |||
| 3 | C (A) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 1 - 306 (UniProt: P0DTC1)
| PDB | External Database | Details |
|---|---|---|
| Phe 50 | Leu 3313 | engineered mutation |
| Ala 166 | Glu 3429 | engineered mutation |
| Phe 167 | Leu 3430 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33835.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 524.6 | |
| All* | Total formula weight | 34360.1 |
