9N1R
Crystal structure of XIAP-BIR3 with ALP2 series SMAC mimetic ligand
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase XIAP | polymer | 110 | 12689.1 | 2 | UniProt (P98170) Pfam (PF00653) | Homo sapiens (human) | Baculoviral IAP repeat-containing protein 4,IAP-like protein,ILP,hILP,Inhibitor of apoptosis protein 3,IAP-3,hIAP-3,hIAP3,RING-type E3 ubiquitin transferase XIAP,X-linked inhibitor of apoptosis protein,X-linked IAP |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F (A, B) | N-{(5M)-5-(3,5-dimethyl-1H-pyrazol-4-yl)-6-[(1,3-thiazol-5-yl)ethynyl]pyridin-2-yl}-N~2~-methyl-L-alaninamide | non-polymer | 380.5 | 2 | Chemie (A1BUO) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B: 246 - 354 (UniProt: P98170)
| PDB | External Database | Details |
|---|---|---|
| Gly 245 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25378.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 891.8 | |
| All* | Total formula weight | 26270.0 |
